Jia Huilin, Liu Chunlei, Lu Yanjuan, He Xiaoge, Lu Qian
School of Nursing, Hebei University, Baoding, Hebei Province, China.
Division of Medical & Surgical Nursing, School of Nursing, Peking University, Haidian District, #38 Xueyuan Road, Beijing, 100191, China.
Breast Cancer Res Treat. 2025 Jul 17. doi: 10.1007/s10549-025-07774-8.
Cancer-related cognitive impairment (CRCI) is one of the most common adverse effects in breast cancer patients, which seriously affects their quality of life. Existing studies have shown that mind-body exercise (MBE) can improve CRCI in breast cancer patients, but the differences in efficacy between various MBEs have not been clarified. This review aimed to evaluate the efficacy of different types of MBEs on CRCI in breast cancer patients through network meta-analysis, and identify the optimal MBE intervention.
Eight databases were searched from their construction up to September 24, 2024. Randomized controlled trials and quasi-randomized controlled trials concerning the effects of MBEs on CRCI in breast cancer patients were included. The Cochrane Risk of Bias Tool 2.0 (RoB 2.0) and the Cochrane-recommended Risk Of Bias In Non-randomized Studies-of Interventions (ROBINS-I) tool were used to assess the quality of the included studies. Network meta-analysis was performed using Stata 18 software.
A total of 20 studies were included, involving 1,353 patients and covering four types of MBEs: yoga, Tai Chi/Qigong, Baduanjin, and dance. The network meta-analysis results showed that Baduanjin, compared with usual care, can alleviate cognitive impairment in breast cancer patients (P < 0.05). Among the four included MBEs, the comparison between Baduanjin and yoga showed statistically significant differences (P < 0.05). The surface under the cumulative ranking curve value indicated that the best MBE for cognitive impairment in breast cancer patients is Baduanjin, followed by yoga and Tai Chi/Qigong.
Baduanjin is the most effective in improving cognitive impairment in breast cancer patients, while yoga, Tai Chi/Qigong, and dance show no significant improvement effects. More large-sample, rigorously designed interventional studies are still needed to further verify the impact of different MBEs on cognitive impairment in breast cancer patients.
癌症相关认知障碍（CRCI）是乳腺癌患者最常见的不良反应之一，严重影响其生活质量。现有研究表明，身心锻炼（MBE）可改善乳腺癌患者的CRCI，但不同类型MBE的疗效差异尚未明确。本综述旨在通过网络荟萃分析评估不同类型MBE对乳腺癌患者CRCI的疗效，并确定最佳的MBE干预措施。
检索了8个数据库，时间跨度从建库至2024年9月24日。纳入了关于MBE对乳腺癌患者CRCI影响的随机对照试验和半随机对照试验。使用Cochrane偏倚风险工具2.0（RoB 2.0）和Cochrane推荐的非随机干预研究中的偏倚风险（ROBINS-I）工具评估纳入研究的质量。使用Stata 18软件进行网络荟萃分析。
共纳入20项研究，涉及1353例患者，涵盖四种类型的MBE：瑜伽、太极拳/气功、八段锦和舞蹈。网络荟萃分析结果显示，与常规护理相比，八段锦可减轻乳腺癌患者的认知障碍（P<0.05）。在纳入的四种MBE中，八段锦与瑜伽的比较显示出统计学显著差异（P<0.05）。累积排序曲线下面积值表明，对乳腺癌患者认知障碍最佳的MBE是八段锦，其次是瑜伽和太极拳/气功。
八段锦在改善乳腺癌患者认知障碍方面最有效，而瑜伽、太极拳/气功和舞蹈未显示出显著的改善效果。仍需要更多大样本、设计严谨的干预研究来进一步验证不同MBE对乳腺癌患者认知障碍的影响。
