Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Department of Chemistry, Jadavpur University, Jadavpur, Kolkata 700032, India.
Biomolecules. 2023 Nov 30;13(12):1723. doi: 10.3390/biom13121723.
BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) derivatives have attracted attention as probes in applications like imaging and sensing due to their unique properties like (1) strong absorption and emission in the visible and near-infrared regions of the electromagnetic spectrum, (2) strong fluorescence and (3) supreme photostability. They have also been employed in areas like photodynamic therapy. Over the last decade, BODIPY-based molecules have even emerged as candidates for cancer treatments. Cancer remains a significant health issue world-wide, necessitating a continuing search for novel therapeutic options. BODIPY is a flexible fluorophore with distinct photophysical characteristics and is a fascinating drug development platform. This review provides a comprehensive overview of the most recent breakthroughs in BODIPY-based small molecules for cancer or disease detection and therapy, including their functional potential.
BODIPY（4,4-二氟-4-硼-3a,4a-二氮杂-s-茚）衍生物因其独特的性质，如（1）在电磁光谱的可见和近红外区域具有强吸收和发射，（2）强荧光和（3）超高光稳定性，在成像和传感等应用中作为探针引起了关注。它们还被应用于光动力治疗等领域。在过去的十年中，基于 BODIPY 的分子甚至已经成为癌症治疗的候选药物。癌症仍然是全球范围内的一个重大健康问题，需要不断寻找新的治疗选择。BODIPY 是一种具有独特光物理特性的灵活荧光团，是一个引人入胜的药物开发平台。本综述全面概述了基于 BODIPY 的小分子在癌症或疾病检测和治疗方面的最新突破，包括它们的功能潜力。
