• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

荧光吡唑衍生物的化学性质与特性：生物成像应用方法

Chemistry and properties of fluorescent pyrazole derivatives: an approach to bioimaging applications.

作者信息

Melo-Hernández Santiago, Ríos María-Camila, Portilla Jaime

机构信息

Bioorganic Compounds Research Group, Department of Chemistry, Universidad de Los Andes Carrera 1 No. 18A-10 Bogotá 111711 Colombia

出版信息

RSC Adv. 2024 Dec 11;14(53):39230-39241. doi: 10.1039/d4ra07485h. eCollection 2024 Dec 10.

DOI:10.1039/d4ra07485h
PMID:39664246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11632951/
Abstract

Fluorescent bioimaging is a crucial technique for studies in real cell samples, providing vital information about the metabolism of ions or molecules of biological and pharmaceutical significance. This technique typically uses probes based on organic small-molecule fluorophores, with N-heteroaromatic scaffolds playing an essential role due to their exceptional electronic properties and biocompatibility. Among these, pyrazole derivatives stand out as particularly promising due to their high synthetic versatility and structural diversity. This review highlights prominent examples from the period 2020-2024, focusing on the chemistry, properties, and bioimaging applications of fluorescent pyrazole derivatives. By highlighting the latest advancements in this field, this manuscript aims to inspire and motivate researchers, emphasizing the potential impact of this work on the future of bioimaging.

摘要

荧光生物成像对于真实细胞样本的研究而言是一项关键技术，它能提供有关具有生物学和药学意义的离子或分子代谢的重要信息。该技术通常使用基于有机小分子荧光团的探针，由于其独特的电子性质和生物相容性，含氮杂芳环支架发挥着至关重要的作用。其中，吡唑衍生物因其高度的合成通用性和结构多样性而显得尤为突出。本综述重点介绍了2020年至2024年期间的突出实例，着重阐述了荧光吡唑衍生物的化学性质、特性及生物成像应用。通过突出该领域的最新进展，本文旨在启发和激励研究人员，强调这项工作对生物成像未来发展的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/a76e2173482f/d4ra07485h-p3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/3306044879f5/d4ra07485h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/a66b82e6ad5d/d4ra07485h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/06dc5a77c6ab/d4ra07485h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/3393e03d6a89/d4ra07485h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/f7e0aa72d175/d4ra07485h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/128ab00c3ff5/d4ra07485h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/e4467f7c3fc8/d4ra07485h-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/96254cf06be3/d4ra07485h-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/17748e2f61fb/d4ra07485h-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/9fcdb159974f/d4ra07485h-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/e8940ad09bde/d4ra07485h-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/31be99bd18d3/d4ra07485h-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/606b4f415596/d4ra07485h-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/6092ac80fc18/d4ra07485h-p2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/a76e2173482f/d4ra07485h-p3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/3306044879f5/d4ra07485h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/a66b82e6ad5d/d4ra07485h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/06dc5a77c6ab/d4ra07485h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/3393e03d6a89/d4ra07485h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/f7e0aa72d175/d4ra07485h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/128ab00c3ff5/d4ra07485h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/e4467f7c3fc8/d4ra07485h-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/96254cf06be3/d4ra07485h-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/17748e2f61fb/d4ra07485h-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/9fcdb159974f/d4ra07485h-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/e8940ad09bde/d4ra07485h-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/31be99bd18d3/d4ra07485h-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/606b4f415596/d4ra07485h-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/6092ac80fc18/d4ra07485h-p2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d8/11632951/a76e2173482f/d4ra07485h-p3.jpg

相似文献

1
Chemistry and properties of fluorescent pyrazole derivatives: an approach to bioimaging applications.荧光吡唑衍生物的化学性质与特性：生物成像应用方法
RSC Adv. 2024 Dec 11;14(53):39230-39241. doi: 10.1039/d4ra07485h. eCollection 2024 Dec 10.
2
Fluorescent Organic Small Molecule Probes for Bioimaging and Detection Applications.用于生物成像和检测应用的荧光有机小分子探针。
Molecules. 2022 Dec 1;27(23):8421. doi: 10.3390/molecules27238421.
3
Recent progress in chemosensors based on pyrazole derivatives.基于吡唑衍生物的化学传感器的最新进展。
RSC Adv. 2020 May 22;10(33):19693-19712. doi: 10.1039/d0ra02394a. eCollection 2020 May 20.
4
Development and Challenge of Fluorescent Probes for Bioimaging Applications: From Visualization to Diagnosis.用于生物成像应用的荧光探针的发展与挑战：从可视化到诊断
Top Curr Chem (Cham). 2022 Apr 12;380(4):22. doi: 10.1007/s41061-022-00376-8.
5
Progress on Multifunction Enzyme-Activated Organic Fluorescent Probes for Bioimaging.用于生物成像的多功能酶激活有机荧光探针的研究进展
Front Chem. 2022 Jul 13;10:935586. doi: 10.3389/fchem.2022.935586. eCollection 2022.
6
Recent highlights in the synthesis and biological significance of pyrazole derivatives.吡唑衍生物的合成及其生物学意义的近期研究要点
Heliyon. 2024 Oct 9;10(20):e38894. doi: 10.1016/j.heliyon.2024.e38894. eCollection 2024 Oct 30.
7
Recent Advances in Calixarenes for the Detection of Metal Ions, Bioimaging Applications, and Anticancer Activities: A Comprehensive Review (2020-2024).用于金属离子检测、生物成像应用和抗癌活性的杯芳烃的最新进展：综述（2020 - 2024年）
Crit Rev Anal Chem. 2024 Sep 16:1-26. doi: 10.1080/10408347.2024.2402820.
8
Small-molecule fluorophores and fluorescent probes for bioimaging.用于生物成像的小分子荧光团和荧光探针。
Pflugers Arch. 2013 Mar;465(3):347-59. doi: 10.1007/s00424-013-1234-z. Epub 2013 Feb 15.
9
Recent advances in dioxaborine-based fluorescent materials for bioimaging applications.用于生物成像应用的基于二氧硼杂环戊烷的荧光材料的最新进展。
Mater Horiz. 2021 Feb 1;8(2):501-514. doi: 10.1039/d0mh01186j. Epub 2020 Nov 16.
10
Multifunctional materials conjugated with near-infrared fluorescent organic molecules and their targeted cancer bioimaging potentialities.与近红外荧光有机分子缀合的多功能材料及其靶向癌症生物成像的潜力。
Biomed Phys Eng Express. 2020 Jan 30;6(1):012003. doi: 10.1088/2057-1976/ab6e1d.

引用本文的文献

1
Five-membered heterocycles as promising platforms for molecular logic gate construction.五元杂环作为构建分子逻辑门的有前景的平台。
RSC Adv. 2025 Apr 4;15(14):10565-10572. doi: 10.1039/d5ra00749f.

本文引用的文献

1
A highly sensitive Golgi-targeted fluorescent probe for the simultaneous detection of malondialdehyde and formaldehyde in living systems and foods.一种高灵敏度的靶向高尔基体的荧光探针，可用于活细胞和食品中丙二醛和甲醛的同时检测。
Talanta. 2024 Oct 1;278:126427. doi: 10.1016/j.talanta.2024.126427. Epub 2024 Jun 17.
2
Hydrazo Pyrazole-Pyridone Fluorescent tag for NLO, Live cell imaging, LFPs visualization, Photophysical probing, and Electrochemical sensor for Dopamine detection.用于 NLO、活细胞成像、LFPs 可视化、光物理探测以及多巴胺检测电化学传感器的 Hydrazo 吡唑并吡啶酮荧光标记物。
Luminescence. 2024 May;39(5):e4760. doi: 10.1002/bio.4760.
3
Pooled multicolour tagging for visualizing subcellular protein dynamics.
多色标记整体染色法用于可视化细胞内蛋白质动态。
Nat Cell Biol. 2024 May;26(5):745-756. doi: 10.1038/s41556-024-01407-w. Epub 2024 Apr 19.
4
Fluorescent Sensor Based on 1-Pyrazolo[3,4-]quinoline Derivative for Detecting Zn Cations.基于1-吡唑并[3,4-]喹啉衍生物的用于检测锌阳离子的荧光传感器。
Molecules. 2024 Feb 10;29(4):823. doi: 10.3390/molecules29040823.
5
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology.含硼化合物的兴起：合成、药物化学和新兴药理学的进展。
Chem Rev. 2024 Mar 13;124(5):2441-2511. doi: 10.1021/acs.chemrev.3c00663. Epub 2024 Feb 21.
6
Tetrazine-Isonitrile Bioorthogonal Fluorogenic Reactions Enable Multiplex Labeling and Wash-Free Bioimaging of Live Cells.四嗪-异腈生物正交荧光反应实现活细胞的多重标记和免洗生物成像。
Angew Chem Int Ed Engl. 2024 Mar 4;63(10):e202319853. doi: 10.1002/anie.202319853. Epub 2024 Feb 2.
7
Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications.基于香豆素的1,2-吡唑的主客体相互作用：采用分析和计算方法的纸条检测、活细胞成像、逻辑门及按键锁应用
Heliyon. 2024 Jan 5;10(1):e24077. doi: 10.1016/j.heliyon.2024.e24077. eCollection 2024 Jan 15.
8
BODIPY-Based Molecules for Biomedical Applications.基于 BODIPY 的分子在生物医学中的应用。
Biomolecules. 2023 Nov 30;13(12):1723. doi: 10.3390/biom13121723.
9
Bacteria-Based Living Probes: Preparation and the Applications in Bioimaging and Diagnosis.基于细菌的活体探针：制备及其在生物成像与诊断中的应用。
Adv Sci (Weinh). 2024 Jan;11(4):e2306480. doi: 10.1002/advs.202306480. Epub 2023 Nov 30.
10
Functional chromophores synthesized via multicomponent Reactions: A review on their use as cell-imaging probes.通过多组分反应合成的功能性发色团：用作细胞成像探针的综述
Methods. 2023 Dec;220:142-157. doi: 10.1016/j.ymeth.2023.11.001. Epub 2023 Nov 6.