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[一名患有桥本甲状腺炎的母亲所生新生儿的短暂性新生儿甲状腺功能减退症]

[Transient neonatal hypothyroidism in a neonate born of a mother with Hashimoto's thyroiditis].

作者信息

Teyssier G, Mermet S, Clavel S, Orgiazzi J, Clavel A M, Freycon M T, Freycon F

出版信息

Arch Fr Pediatr. 1986 Oct;43(8):629-31.

PMID:3813787
Abstract

Transient neonatal hypothyroidism was found in a boy whose mother was treated for hypothyroidism due to Hashimoto's thyroiditis. During the neonatal period the infant had antithyroid microsomal and antithyroglobulin antibodies and immunoglobulins inhibiting cyclic AMP production by thyroid cells in vitro. After one year of treatment, all antibodies disappeared. Thyroid scintiscan and fixation in the neonatal period was negative and became positive 2 months after stopping treatment with normal fixation and cervical thyroid picture. The mother's serum contained the same antibodies: they crossed the placental barrier and were responsible for neonatal pathological manifestations.

摘要

在一名母亲因桥本甲状腺炎接受甲状腺功能减退治疗的男婴中发现了短暂性新生儿甲状腺功能减退。在新生儿期,该婴儿具有抗甲状腺微粒体和抗甲状腺球蛋白抗体以及在体外抑制甲状腺细胞产生环磷酸腺苷的免疫球蛋白。经过一年的治疗,所有抗体均消失。新生儿期的甲状腺闪烁扫描和固定检查为阴性,在停止治疗2个月后变为阳性,甲状腺固定和颈部甲状腺影像正常。母亲的血清中含有相同的抗体:它们穿过胎盘屏障并导致新生儿出现病理表现。

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