Department of Periodontics, School of Dentistry, Loma Linda University, Loma Linda, CA 92350, USA.
Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Medicina (Kaunas). 2023 Nov 28;59(12):2089. doi: 10.3390/medicina59122089.
: An obesity-related elevated body mass index (BMI) across life is associated with chronic low-grade inflammation and increased levels of C-reactive protein (CRP) in blood. CRP is a marker and promoter of inflammation. The objectives of this study were to examine the effect of obesity on the relationship between peripheral and gingival CRP levels and to examine the effects of gingival CRP levels on gingival fluid inflammatory cytokines in periodontitis-resistant obese individuals. : Thirty-nine participants in good periodontal health were recruited. Twenty patients were classified as lean and nineteen as obese based on their BMI levels. A thorough periodontal assessment was carried out. Gingival crevicular fluid (GCF) and blood samples were collected. Both GCF and blood samples were analyzed for interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), interleukin-17A (IL-17A), and CRP. : GCF CRP levels were significantly higher in the obese than in the lean individuals. No statistically significant differences were noted between the two groups in either GCF or blood in terms of any of the inflammatory cytokine levels. IL-17A was not detected in the GCF of most subjects in both groups. GCF CRP levels were positively associated with blood CRP levels, and the association tended to be stronger in the obese individuals. GCF CRP showed no associations with GCF IL-10 in both groups. Although GCF CRP levels were positively associated with multiple GCF inflammatory cytokines (e.g., IL-1β, IL-6, IL-8, and TNF-α) in all subjects, the associations tended to be weaker in the obese individuals (e.g., IL-1β, IL-6, and TNF-α). Furthermore, the levels of the GCF inflammatory cytokines IL-6 and TNF-α were decreased in the obese individuals. : Obesity unfavorably influences the relationship between blood and GCF CRP levels and promotes increased CRP levels in GCF. Collectively, the findings suggest a weakened inflammatory cytokine response in the gingival tissues of obese individuals.
肥胖相关的体质量指数（BMI）升高与慢性低度炎症和血液中 C 反应蛋白（CRP）水平升高有关。CRP 是炎症的标志物和促进因素。本研究的目的是探讨肥胖对牙周炎抵抗肥胖个体外周和牙龈 CRP 水平之间关系的影响，并探讨牙龈 CRP 水平对牙周炎患者牙龈液中炎性细胞因子的影响。
共招募了 39 名牙周健康状况良好的参与者。根据 BMI 水平，20 名患者被归类为瘦，19 名患者被归类为胖。进行了全面的牙周评估。收集牙龈沟液（GCF）和血液样本。分析 GCF 和血液样本中的白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）、白细胞介素-17A（IL-17A）和 CRP。
肥胖组的 GCF CRP 水平明显高于瘦组。两组的 GCF 或血液中的任何炎性细胞因子水平均无统计学差异。两组中大多数受试者的 GCF 中均未检测到 IL-17A。GCF CRP 水平与血液 CRP 水平呈正相关，这种相关性在肥胖组中更强。GCF CRP 与两组的 GCF IL-10 均无相关性。虽然 GCF CRP 水平与所有受试者的多个 GCF 炎性细胞因子（如 IL-1β、IL-6、IL-8 和 TNF-α）呈正相关，但在肥胖组中这种相关性较弱（如 IL-1β、IL-6 和 TNF-α）。此外，肥胖组的 GCF 炎性细胞因子 IL-6 和 TNF-α 水平降低。
肥胖对血液和 GCF CRP 水平之间的关系产生不利影响，并促进 GCF 中 CRP 水平的升高。综上所述，这些发现表明肥胖个体牙龈组织中的炎性细胞因子反应减弱。
