Department of Nursing, Tzu Chi University of Science and Technology, Hualien 970302, Taiwan.
Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
Medicina (Kaunas). 2023 Nov 29;59(12):2097. doi: 10.3390/medicina59122097.
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that affects multiple organ systems and manifests in a relapsing-remitting pattern. Consequently, it is paramount for rheumatologists to assess disease activity, identify flare-ups, and establish treatment goals for patients with SLE. In 2019, the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) was introduced as a novel tool for measuring disease activity. This tool refines the parameters of the established SLE Disease Activity Index 2000 (SLEDAI-2K) to enhance the assessment process. This review aims to provide an introduction to the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) and summarizes research on its development, its comparison with existing disease activity measures, and its performance in clinical settings. Literature searches on PubMed using the keyword "SLE-DAS" were conducted, covering publications from March 2019 to September 2023. Studies that compared SLE-DAS with other SLE disease activity measurement tools were reviewed. Findings indicated that SLE-DAS consistently performs on par with, and sometimes better than, traditional measures in assessing clinically meaningful changes, patient improvement, disease activity, health-related quality of life, hospitalization rates, and disease flare-ups. The association between SLE-DAS and mortality rates among patients with SLE, however, remains to be further explored. Although SLE-DAS is a promising and potentially effective tool for measuring SLE disease activity, additional research is needed to confirm its effectiveness and broaden its clinical use.
系统性红斑狼疮（SLE）是一种慢性全身性自身免疫性疾病，影响多个器官系统，呈反复发作缓解的模式。因此，风湿科医生评估疾病活动度、识别病情加重并为 SLE 患者制定治疗目标至关重要。2019 年，推出了系统性红斑狼疮疾病活动评分（SLE-DAS）作为衡量疾病活动度的新工具。该工具改进了既定的系统性红斑狼疮疾病活动指数 2000（SLEDAI-2K）的参数，以增强评估过程。本综述旨在介绍系统性红斑狼疮疾病活动评分（SLE-DAS），总结其开发研究、与现有疾病活动测量指标的比较及其在临床环境中的表现。使用关键词“ SLE-DAS ”在 PubMed 上进行文献检索，涵盖了 2019 年 3 月至 2023 年 9 月的出版物。综述了将 SLE-DAS 与其他 SLE 疾病活动测量工具进行比较的研究。研究结果表明，SLE-DAS 在评估临床有意义的变化、患者改善、疾病活动、健康相关生活质量、住院率和病情加重方面，与传统指标表现一致，有时甚至更好。然而，SLE-DAS 与 SLE 患者死亡率之间的关联仍需进一步探讨。尽管 SLE-DAS 是衡量 SLE 疾病活动度的一种有前途且潜在有效的工具，但仍需要更多的研究来确认其有效性并扩大其临床应用。
