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. 的化学成分及对 α-葡萄糖苷酶的抑制作用、抗氧化和保肝活性

Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of .

机构信息

TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

Zhangjiajie Meicha Technology Research Center, Hunan Qiankun Biotechnology Co., Ltd., Zhangjiajie 427099, China.

出版信息

Molecules. 2023 Dec 5;28(24):7956. doi: 10.3390/molecules28247956.

Abstract

is a valuable medicinal and edible plant, which is often used as a traditional tea by the Tujia people in China. has numerous biological activities and is now widely used in the pharmaceutical and food industries. In this study, two new flavonoids (-) and seventeen known compounds (-) were isolated and identified from the dried stems and leaves of . These isolated compounds were characterized by various spectroscopic data including mass spectrometry and nuclear magnetic resonance spectroscopy. All isolates were assessed for their α-glucosidase inhibitory, antioxidant, and hepatoprotective activities, and their structure-activity relationships were further discussed. The results indicated that compound exhibited effective inhibitory activity against α-glucosidase, with an IC value of 0.21 μM. In addition, compounds - demonstrated not only potent antioxidant activities but also superior hepatoprotective properties. The findings of this study could serve as a reference for the development of products or drugs aimed at realizing their antidiabetic, antioxidant, and hepatoprotective functions.

摘要

淫羊藿是一种有价值的药用和食用植物,常被中国土家族人用作传统茶。淫羊藿具有多种生物活性,现在被广泛应用于制药和食品工业。在这项研究中,从淫羊藿的干茎和叶中分离并鉴定出两种新的黄酮类化合物(-)和十七种已知化合物(-)。这些分离出的化合物通过各种光谱数据(包括质谱和核磁共振波谱)进行了表征。所有分离物均评估了其对α-葡萄糖苷酶的抑制、抗氧化和保肝活性,并进一步讨论了它们的构效关系。结果表明,化合物-对α-葡萄糖苷酶表现出有效的抑制活性,IC 值为 0.21 μM。此外,化合物-不仅表现出强大的抗氧化活性,还具有优异的保肝特性。本研究的结果可为开发具有降血糖、抗氧化和保肝功能的淫羊藿产品或药物提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c7/10745659/7773d56fce49/molecules-28-07956-g001.jpg

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