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基于力学性能和渗透性的多孔钽支架设计的微观结构优化

Microstructure Optimization for Design of Porous Tantalum Scaffolds Based on Mechanical Properties and Permeability.

作者信息

Wang Yikai, Qin Xiao, Lv Naixin, Gao Lin, Sun Changning, Tong Zhiqiang, Li Dichen

机构信息

State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710054, China.

National Medical Products Administration (NMPA), Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi'an 710054, China.

出版信息

Materials (Basel). 2023 Dec 8;16(24):7568. doi: 10.3390/ma16247568.

Abstract

Porous tantalum (Ta) implants have important clinical application prospects due to their appropriate elastic modulus, and their excellent bone growth and bone conduction ability. However, porous Ta microstructure designs generally mimic titanium (Ti) implants commonly used in the clinic, and there is a lack of research on the influence of the microstructure on the mechanical properties and penetration characteristics, which will greatly affect bone integration performance. This study explored the effects of different microstructure parameters, including the fillet radius of the middle plane and top planes, on the mechanics and permeability properties of porous Ta diamond cells through simulation, and put forward an optimization design with a 0.5 mm midplane fillet radius and 0.3 mm top-plane fillet radius in order to significantly decrease the stress concentration effect and improve permeability. On this basis, the porous Ta structures were prepared by Laser Powder Bed Fusion (LPBF) technology and evaluated before and after microstructural optimization. The elastic modulus and the yield strength were increased by 2.31% and 10.39%, respectively. At the same time, the permeability of the optimized structure was also increased by 8.25%. The optimized microstructure design of porous Ta has important medical application value.

摘要

多孔钽(Ta)植入物因其合适的弹性模量以及出色的骨生长和骨传导能力而具有重要的临床应用前景。然而,多孔钽的微观结构设计通常模仿临床上常用的钛(Ti)植入物,并且缺乏关于微观结构对力学性能和渗透特性影响的研究,这将极大地影响骨整合性能。本研究通过模拟探讨了不同微观结构参数,包括中间平面和顶部平面的圆角半径,对多孔钽菱形单元力学性能和渗透性能的影响,并提出了一种优化设计,即中间平面圆角半径为0.5mm,顶部平面圆角半径为0.3mm,以显著降低应力集中效应并提高渗透性。在此基础上,采用激光粉末床熔融(LPBF)技术制备了多孔钽结构,并对微观结构优化前后进行了评估。弹性模量和屈服强度分别提高了2.31%和10.39%。同时,优化结构的渗透率也提高了8.25%。多孔钽的优化微观结构设计具有重要的医学应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af0f/10744872/500696093732/materials-16-07568-g001.jpg

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