Jalali Rakesh, Godlewska Izabela, Fadrowska-Szleper Magdalena, Pypkowska Agata, Kern Adam, Bil Jacek, Manta Joanna, Romaszko Jerzy
Department of Emergency Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, Poland.
Clinical Emergency Department, Regional Specialist Hospital, 10-561 Olsztyn, Poland.
J Pers Med. 2023 Dec 18;13(12):1724. doi: 10.3390/jpm13121724.
Traumatic brain injuries (TBIs) are not only the leading cause of death among people below 44 years of age, but also one of the biggest diagnostic challenges in the emergency set up. We believe that the use of serum biomarkers in diagnosis can help to improve patient care in TBI. One of them is the S100B protein, which is currently proposed as a promising diagnostic tool for TBI and its consequences. In our study, we analyzed serum biomarker S100B in 136 patients admitted to the Emergency Department of the Regional Specialist Hospital in Olsztyn. Participants were divided into three groups: patients with head trauma and alcohol intoxication, patients with head trauma with no alcohol intoxication and a control group of patients with no trauma or with injury in locations other than the head. In our study, as compared to the control group, patients with TBI had a significantly higher S100B level (both with and without intoxication). Moreover, in both groups, the mean S100B protein level was significantly higher in patients with pathological changes in CT. According to our study results, the S100B protein is a promising diagnostic tool, and we propose including its evaluation in routine regimens in patients with TBI.
创伤性脑损伤（TBIs）不仅是44岁以下人群的主要死因，也是急诊环境中最大的诊断挑战之一。我们认为，在诊断中使用血清生物标志物有助于改善创伤性脑损伤患者的护理。其中之一是S100B蛋白，目前它被认为是一种有前景的用于诊断创伤性脑损伤及其后果的工具。在我们的研究中，我们分析了奥尔什丁地区专科医院急诊科收治的136例患者的血清生物标志物S100B。参与者被分为三组：头部外伤合并酒精中毒患者、头部外伤但无酒精中毒患者以及无创伤或头部以外部位受伤的对照组患者。在我们的研究中，与对照组相比，创伤性脑损伤患者（无论有无中毒）的S100B水平显著更高。此外，在两组中，CT有病理改变的患者的平均S100B蛋白水平显著更高。根据我们的研究结果，S100B蛋白是一种有前景的诊断工具，我们建议在创伤性脑损伤患者的常规治疗方案中纳入对其的评估。
