Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15269 Bialystok, Poland.
Department of Aesthetic Medicine, Medical University of Bialystok, 15267 Bialystok, Poland.
Int J Mol Sci. 2023 Dec 5;24(24):17139. doi: 10.3390/ijms242417139.
Bone tissue is a dynamic structure that is involved in maintaining the homeostasis of the body due to its multidirectional functions, such as its protective, endocrine, or immunological role. Specialized cells and the extracellular matrix (ECM) are responsible for the remodeling of specific bone structures, which alters the biomechanical properties of the tissue. Imbalances in bone-forming elements lead to the formation and progression of bone diseases. The most important family of enzymes responsible for bone ECM remodeling are matrix metalloproteinases (MMPs)-enzymes physiologically present in the body's tissues and cells. The activity of MMPs is maintained in a state of balance; disruption of their activity is associated with the progression of many groups of diseases, including those of the skeletal system. This review summarizes the current understanding of the role of MMPs in bone physiology and the pathophysiology of bone tissue and describes their role in specific skeletal disorders. Additionally, this work collects data on the potential of MMPs as bio-markers for specific skeletal diseases.
骨骼组织是一种具有多向功能的动态结构，它在维持机体的内环境稳定方面发挥着重要作用，例如保护、内分泌或免疫作用。特定的细胞和细胞外基质（ECM）负责重塑特定的骨骼结构，从而改变组织的生物力学特性。成骨元素的失衡会导致骨骼疾病的发生和发展。负责骨骼 ECM 重塑的最重要的酶家族是基质金属蛋白酶（MMPs）-这些酶在体内组织和细胞中生理性存在。MMPs 的活性处于平衡状态；其活性的破坏与许多疾病群体的进展有关，包括骨骼系统的疾病。本综述总结了 MMPs 在骨骼生理学和骨骼组织病理生理学中的作用，并描述了它们在特定骨骼疾病中的作用。此外，这项工作还收集了 MMPs 作为特定骨骼疾病生物标志物的潜力的数据。
