Kulesza Monika, Guszczyn Tomasz, Kicman Aleksandra, Ławicki Sławomir
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15-269 Bialystok, Poland.
Department of Pediatric Orthopaedics and Traumatology, Medical University of Bialystok, 15-274 Bialystok, Poland.
J Clin Med. 2024 Sep 24;13(19):5655. doi: 10.3390/jcm13195655.
: Osgood-Schlatter disease (OSD) belongs to the group of sterile bone necrosis and mainly affects athletically active children. The pathogenesis of OSD is currently not fully understood, so the purpose of this study was to evaluate the concentrations of selected matrix metalloproteinases (MMPs)-MMP-2, MMP-3, MMP-7, MMP-9, MMP-10 and MMP-26 in patients diagnosed with OSD compared to patients with diseases other than sterile bone necrosis : The study group included 140 patients with OSD, while the control group contained 100 patients with knee pain unrelated to sterile bone necrosis. The MMPs tested were determined by an enzyme-linked immunosorbent assay in plasma. : Patients with OSD had higher concentrations of MMP-2 and MMP-9 compared to the control group. The concentrations of MMP-7, MMP-10 and MMP-26 were lower in affected children. High values of diagnostic parameters-diagnostic accuracy (AC), sensitivity (SE), specificity (SP) and area under curve (AUC)-were obtained for MMP-7, MMP-9 and MMP-26. : The collected results convince that MMP-7, MMP-9 and MMP-26 can be consider as a differential ancillary test between OSD and other knee pain and may be involved in the pathogenesis of this condition.
奥斯古德-施拉特病（OSD）属于无菌性骨坏死疾病组，主要影响体育活动活跃的儿童。目前对OSD的发病机制尚未完全了解，因此本研究的目的是评估与非无菌性骨坏死疾病患者相比，被诊断为OSD的患者中选定的基质金属蛋白酶（MMPs）——MMP-2、MMP-3、MMP-7、MMP-9、MMP-10和MMP-26的浓度。研究组包括140例OSD患者，而对照组包含100例与无菌性骨坏死无关的膝关节疼痛患者。通过酶联免疫吸附测定法测定血浆中所检测的MMPs。与对照组相比，OSD患者的MMP-2和MMP-9浓度更高。患病儿童中MMP-7、MMP-10和MMP-26的浓度较低。MMP-7、MMP-9和MMP-26获得了较高的诊断参数值——诊断准确性（AC）、敏感性（SE）、特异性（SP）和曲线下面积（AUC）。所收集的结果表明，MMP-7、MMP-9和MMP-26可被视为OSD与其他膝关节疼痛之间的鉴别辅助检查，并且可能参与了这种疾病的发病机制。
