Queen Mary College, Nanchang University, Xuefu Road, Nanchang 330001, China.
School of Pharmacy, Nanchang University, Nanchang 330006, China.
Int J Mol Sci. 2023 Dec 8;24(24):17254. doi: 10.3390/ijms242417254.
Ghrelin, comprising 28 amino acids, was initially discovered as a hormone that promotes growth hormones. The original focus was on the effects of ghrelin on controlling hunger and satiation. As the research further develops, the research scope of ghrelin has expanded to a wide range of systems and diseases. Nevertheless, the specific mechanisms remain incompletely understood. In recent years, substantial studies have demonstrated that ghrelin has anti-inflammatory, antioxidant, antiapoptotic, and other effects, which could affect the signaling pathways of various kinds of programmed cell death (PCD) in treating diseases. However, the regulatory mechanisms underlying the function of ghrelin in different kinds of PCD have not been thoroughly illuminated. This review describes the relationship between ghrelin and four kinds of PCD (apoptosis, necroptosis, autophagy, and pyroptosis) and then introduces the clinical applications based on the different features of ghrelin.
胃饥饿素由 28 个氨基酸组成，最初被发现是一种促进生长激素分泌的激素。最初的研究重点是胃饥饿素对控制饥饿和饱腹感的影响。随着研究的进一步发展，胃饥饿素的研究范围已经扩展到广泛的系统和疾病。然而，其具体机制仍不完全清楚。近年来，大量研究表明，胃饥饿素具有抗炎、抗氧化、抗细胞凋亡等作用，可能影响各种程序性细胞死亡（PCD）的信号通路，从而治疗疾病。然而，胃饥饿素在不同类型 PCD 中的功能的调控机制尚未被完全阐明。本综述描述了胃饥饿素与四种 PCD（细胞凋亡、坏死性凋亡、自噬和细胞焦亡）之间的关系，然后根据胃饥饿素的不同特点介绍了其临床应用。
