McDougald L R, Fuller L, Solis J
Avian Dis. 1986 Oct-Dec;30(4):690-4.
Coccidia were isolated from 99 broiler farms in 12 broiler-producing states and tested for sensitivity to contemporary anticoccidial drugs. The isolates usually comprised two or more species, including 92 Eimeria acervulina, 47 E. maxima, 28 E. tenella, and 10 E. brunetti. Based on intestinal-lesion-score reduction of 30% or more, 38% of isolates were resistant to monensin (110 ppm), 29% to salinomycin (60 ppm), 20% to nicarbazin (125 ppm), and 46% to amprolium + ethopabate (125 + 4 ppm). Isolates with 50% or greater reduction of lesion scores were considered sensitive. Thirty-three percent were sensitive to monensin, 53% to salinomycin, 67% to nicarbazin, and 39% to amprolium + ethopabate. Other isolates had intermediate response to drugs and were considered to have "reduced sensitivity." There was some evidence for incomplete cross resistance to the polyether, ionophorous products.
从12个肉鸡生产州的99个肉鸡场分离出球虫，并检测其对当代抗球虫药物的敏感性。分离株通常包含两种或更多种，包括92株堆型艾美耳球虫、47株巨型艾美耳球虫、28株柔嫩艾美耳球虫和10株布氏艾美耳球虫。基于肠道病变评分降低30%或更多，38%的分离株对莫能菌素（110 ppm）耐药，29%对盐霉素（60 ppm）耐药，20%对尼卡巴嗪（125 ppm）耐药，46%对氨丙啉+乙氧酰胺苯甲酯（125 + 4 ppm）耐药。病变评分降低50%或更多的分离株被认为敏感。33%对莫能菌素敏感，53%对盐霉素敏感，67%对尼卡巴嗪敏感，39%对氨丙啉+乙氧酰胺苯甲酯敏感。其他分离株对药物有中等反应，被认为具有“敏感性降低”。有一些证据表明对聚醚类离子载体产品存在不完全交叉耐药性。
