Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 03080, Republic of Korea.
Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul 01811, Republic of Korea.
Nutrients. 2023 Dec 8;15(24):5040. doi: 10.3390/nu15245040.
Our objective was to determine whether nutritional status correlates with mortality in sepsis patients. Data from a nationwide registration database were utilized for this population-based cohort study. The study subjects comprised adults who received standard health examinations before being admitted to the hospital for sepsis and were diagnosed with sepsis between 2018 and 2020. Nutrition scores were evaluated using the Nutritional Lifestyle Assessment Tool in South Korea. Overall, 2482 patients with sepsis were included in this study. The 90-day and 1-year mortality rates in patients with sepsis were 26.8% (664/2482) and 34.2% (848/2482), respectively. In the covariate-adjusted multivariable logistic regression model, a 1-point increase in nutrition score was associated with a decrease in 90-day mortality in patients with sepsis (odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.97, 0.98; = 0.025). In the covariate-adjusted multivariable Cox regression model, a 1-point increase in nutrition score was associated with a decrease in 1-year mortality in patients with sepsis (hazard ratio [H.R.]: 0.99, 95% CI: 0.98, 0.99; = 0.035). Our results suggest that adequate dietary intake and healthy eating habits might protect against mortality among sepsis patients.
我们的目的是确定营养状况是否与脓毒症患者的死亡率相关。这项基于人群的队列研究使用了全国性登记数据库的数据。研究对象包括在因脓毒症住院前接受过标准健康检查并在 2018 年至 2020 年间被诊断为脓毒症的成年人。使用韩国的营养生活方式评估工具评估营养评分。共有 2482 名脓毒症患者纳入本研究。脓毒症患者的 90 天和 1 年死亡率分别为 26.8%(664/2482)和 34.2%(848/2482)。在调整协变量的多变量逻辑回归模型中,营养评分每增加 1 分,与脓毒症患者 90 天死亡率降低相关(优势比 [OR]:0.98,95%置信区间 [CI]:0.97,0.98; = 0.025)。在调整协变量的多变量 Cox 回归模型中,营养评分每增加 1 分,与脓毒症患者 1 年死亡率降低相关(风险比 [H.R.]:0.99,95% CI:0.98,0.99; = 0.035)。我们的研究结果表明,适当的饮食摄入和健康的饮食习惯可能有助于预防脓毒症患者的死亡。