Overmier J B, Murison R, Ursin H
Behav Neural Biol. 1986 Nov;46(3):372-82. doi: 10.1016/s0163-1047(86)90359-6.
Shock-induced gastric ulceration in rats is exacerbated by allowing animals to rest between the period of stress and sacrifice. Conflicting data have been reported for similar post-stress rest effects using restraint stress. In Experiment 1, rats restrained in water for 2 h and then allowed a 2-h rest period exhibited significantly greater gastric ulceration than rats sacrificed immediately after the 2-h restraint-in-water stress period. The strength of this phenomenon is confirmed by Experiment 2, in which rats challenged with restraint in water for 1.25 h and then allowed a 1.25-h rest period before sacrifice exhibited greater ulceration than animals maintained in the restraint-in-water stress for the full 2 1/2 h. Corticosterone levels for these two treatment groups were similar at the time of sacrifice. Post-stressor rest therefore actively contributes to the ulcerogenic processes initiated by this form of stress challenge.
在应激期和处死之间让大鼠休息，会加剧休克诱导的大鼠胃溃疡。关于使用束缚应激的类似应激后休息效应，已有相互矛盾的数据报道。在实验1中，在水中束缚2小时然后给予2小时休息期的大鼠，比在2小时水中束缚应激期后立即处死的大鼠表现出明显更严重的胃溃疡。实验2证实了这种现象的强度，在实验2中，在水中束缚1.25小时然后在处死前给予1.25小时休息期的大鼠，比在水中束缚应激状态下持续2.5小时的动物表现出更严重的溃疡。这两个治疗组在处死时的皮质酮水平相似。因此，应激后休息会积极促进这种应激挑战形式引发的致溃疡过程。
