Glavin G B
Life Sci. 1985 Aug 5;37(5):461-5. doi: 10.1016/0024-3205(85)90408-4.
Rats were given FLA-63, followed by R04-1284 0.5 h later to relatively selectively deplete brain NA. After 8 h, some animals were examined for regional brain NA and MHPG-SO4, while some were subjected to 3 h of cold-restraint stress and then examined. All brain regions examined showed significant NA and MHPG reduction. Specific NA depletion markedly exacerbated restraint ulcer formation and plasma corticosterone levels. NA depletion without restraint stress did not induce ulcers or elevate corticosterone. Intact brain NA activity appears to be essential for coping with stress.
给大鼠注射FLA - 63，0.5小时后再注射R04 - 1284，以相对选择性地耗尽脑内去甲肾上腺素（NA）。8小时后，对一些动物检测脑内各区域的NA和3 - 甲氧基 - 4 - 羟基苯乙二醇硫酸酯（MHPG - SO4），而对另一些动物施加3小时的冷束缚应激，然后进行检测。所有检测的脑区均显示NA和MHPG显著减少。特异性NA耗竭明显加剧了束缚性溃疡的形成和血浆皮质酮水平。没有束缚应激的NA耗竭不会诱发溃疡或升高皮质酮。完整的脑内NA活性似乎对应对压力至关重要。
