Murison R, Overmier J B, Skoglund E J
Behav Neural Biol. 1986 Mar;45(2):185-95. doi: 10.1016/s0163-1047(86)90761-2.
Several studies have focused on the proactive effects of prior exposure to a stressor on ulcerogenic and endocrine responses to exposure to a similar final stressor. In the present study, we explored the effects of prior exposure of Møll-Wistar rats to water-restraint stress on gastric ulceration and corticosterone responses to a final stressor. The number of prior exposures to water-restraint challenge was varied from one to four, and the durations of the prior exposures varied from 30 min to 2 h. The duration of the final stress challenge was 75 min. The two indices of the stress response to the final stressor challenge yielded different results. For neither index was the duration of prior exposures a significant factor in modulating the response to the final challenge. For gastric ulceration, those animals receiving one prior exposure, but not four, exhibited less gastric ulceration than animals receiving no prior exposure. These animals also developed less ulceration than those receiving four prior exposures. For corticosterone, those animals receiving four prior exposures exhibited a lower adrenocortical response to the final stressor than did animals receiving no prior exposure, or only one prior exposure. The results indicate the complexity of proactive effects of earlier stress experience on responses to a final stressor challenge.
多项研究聚焦于先前暴露于应激源对暴露于类似最终应激源时致溃疡和内分泌反应的前瞻性影响。在本研究中，我们探究了先前使莫尔-威斯塔大鼠暴露于禁水应激对胃溃疡形成以及对最终应激源的皮质酮反应的影响。先前暴露于禁水挑战的次数从1次到4次不等，先前暴露的持续时间从30分钟到2小时不等。最终应激挑战的持续时间为75分钟。对最终应激源挑战的应激反应的两个指标产生了不同的结果。对于这两个指标而言，先前暴露的持续时间均不是调节对最终挑战反应的显著因素。对于胃溃疡形成，那些接受1次先前暴露而非4次先前暴露的动物，与未接受先前暴露的动物相比，胃溃疡形成较少。这些动物的溃疡形成也比接受4次先前暴露的动物少。对于皮质酮，那些接受4次先前暴露的动物对最终应激源的肾上腺皮质反应低于未接受先前暴露或仅接受1次先前暴露的动物。结果表明早期应激经历对最终应激源挑战反应的前瞻性影响具有复杂性。
