José Barberán, Hospital Universitario HM Montepríncipe, Facultad HM Hospitales de Ciencias de la Salud, Universidad Camilo José Cela, Madrid, Spain.
Rev Esp Quimioter. 2024 Apr;37(2):127-133. doi: 10.37201/req/143.2023. Epub 2023 Dec 22.
Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, the alarms issued by regulatory agencies and therapeutic alternatives.
氟喹诺酮类药物（FQs）是最常用的抗生素类别之一。尽管它们在随机临床试验中最初被很好地耐受，但随后的流行病学研究报告了与神经毒性和胶原降解相关的威胁性、严重、持久、致残和不可逆转的不良事件（AE）的风险增加，如肌腱炎、跟腱断裂、主动脉瘤和视网膜脱离。本文综述了主要的潜在威胁性 AE、监管机构发出的警报以及治疗替代方案。
