At the time this article was written, Anne Wildermuth was an assistant professor and Megan Holmes was a student in the PA program at the University of Nebraska Medical Center in Omaha. Ms. Wildermuth now is the associate program director and an assistant professor in the PA program at George Washington University in Washington, D.C. Ms. Holmes now practices at Bryan Heart Vascular Surgery in Lincoln, Neb. The authors have disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2022 Nov 1;35(11):33-36. doi: 10.1097/01.JAA.0000873776.37967.9b.
Fluoroquinolones, such as ciprofloxacin and levofloxacin, are broad-spectrum antibacterial agents that have historically been widely used for urinary tract infections, pneumonia, and intra-abdominal infections but are associated with several serious adverse reactions, including tendinopathy and tendon rupture, peripheral neuropathy, and aortic aneurysm. These drugs should not be used for uncomplicated infections unless no other antimicrobial treatment is feasible. This article describes a patient who experienced life-altering disability from a fluoroquinolone, reviews the adverse reactions of this drug class, and discusses recommended treatment for acute uncomplicated cystitis and asymptomatic bacteriuria.
氟喹诺酮类药物，如环丙沙星和左氧氟沙星，是一种广谱抗菌药物，历史上被广泛用于治疗尿路感染、肺炎和腹腔内感染，但与多种严重不良反应有关，包括肌腱病和肌腱断裂、周围神经病和主动脉瘤。除非没有其他抗菌治疗方法可行，否则这些药物不应用于单纯感染。本文描述了一位因氟喹诺酮类药物而致残的患者，回顾了该类药物的不良反应，并讨论了急性单纯性膀胱炎和无症状菌尿症的推荐治疗方法。
