一种芽孢杆菌属细菌对17-羟孕酮的代谢
Metabolism of 17-hydroxyprogesterone by a Bacillus species.
作者信息
Mahato S B, Banerjee S
出版信息
Biochem J. 1986 Oct 15;239(2):473-6. doi: 10.1042/bj2390473.
Abstract
Fermentation of 17-hydroxyprogesterone with a Bacillus species (IICB-301) in a modified nutrient medium under aerobic conditions yielded androst-4-ene-3,17-dione and 15 alpha,17-dihydroxypregn-4-ene-3,20-dione in addition to a new pregnane analogue, 6 beta,17,20 alpha-trihydroxypregn-4-ene-3-one. Each microbial metabolite was characterized by the application of various spectroscopic techniques. The availability of the new metabolite, 6 beta,17,20 alpha-trihydroxypregn-4-ene-3-one, enabled complete elucidation of its 13C-n.m.r. spectrum.
摘要
在有氧条件下，在改良的营养培养基中用一种芽孢杆菌属（IICB - 301）发酵17 - 羟基孕酮，除了产生一种新的孕烷类似物6β,17,20α - 三羟基孕 - 4 - 烯 - 3 - 酮外，还产生了雄甾 - 4 - 烯 - 3,17 - 二酮和15α,17 - 二羟基孕 - 4 - 烯 - 3,20 - 二酮。通过应用各种光谱技术对每种微生物代谢产物进行了表征。新代谢产物6β,17,20α - 三羟基孕 - 4 - 烯 - 3 - 酮的可得性使得能够完全解析其13C - 核磁共振谱。
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