两种新型孕酮衍生物的微生物转化产物。

Two novel microbial conversion products of progesterone derivatives.

作者信息

Krischenowski D, Kieslich K

机构信息

Gesellschaft für Biotechnologische Forschung mbH, Research Group of Microbial Transformations, Braunschweig, Germany.

出版信息

Steroids. 1993 Jun;58(6):278-81. doi: 10.1016/0039-128x(93)90073-v.

DOI:10.1016/0039-128x(93)90073-v

PMID:8212074

Abstract

Two novel microbial steroid hydroxylations were found in a screening of 131 microorganisms under aerobic conditions. 17 alpha-Hydroxyprogesterone was hydroxylated in the 8 beta-position by Corynespora melonis CBS 16260, and fermentation of 17 alpha-acetoxyprogesterone with Pycnosporium species ATCC 12231 yielded 11 beta-hydroxy- and 11 beta, 12 beta-dihydroxy-17 alpha-acetoxyprogesterone. The known 11 beta-hydroxy compound could be obtained as a single product with Trichothecium roseum ATCC 12519.

摘要

在需氧条件下对131种微生物进行筛选时，发现了两种新的微生物甾体羟基化反应。甜瓜棒孢菌CBS 16260将17α-羟基孕酮在8β位进行羟基化，用短梗孢属菌种ATCC 12231发酵17α-乙酰氧基孕酮可产生11β-羟基-和11β,12β-二羟基-17α-乙酰氧基孕酮。已知的11β-羟基化合物可以用玫红单端孢霉ATCC 12519作为单一产物获得。