大鼠的嗅觉腺苷酸环化酶。气味剂的刺激作用和Ca2+的抑制作用。
Olfactory adenylate cyclase of the rat. Stimulation by odorants and inhibition by Ca2+.
作者信息
Shirley S G, Robinson C J, Dickinson K, Aujla R, Dodd G H
出版信息
Biochem J. 1986 Dec 1;240(2):605-7. doi: 10.1042/bj2400605.
Abstract
Membranes prepared from the olfactory mucosa of the rat show a high level of adenylate cyclase activity. The activity increases up to 2-fold in the presence of physiologically relevant concentrations of odorants and is inhibited by Ca2+. The level of cyclase activity found is sufficient to explain the speed of olfactory transduction, which occurs on a time scale of tens of milliseconds.
摘要
从大鼠嗅黏膜制备的膜显示出高水平的腺苷酸环化酶活性。在生理相关浓度的气味剂存在下，该活性增加至2倍，并受到Ca2+的抑制。所发现的环化酶活性水平足以解释嗅觉转导的速度，嗅觉转导发生在几十毫秒的时间尺度上。
相似文献
1
Olfactory adenylate cyclase of the rat. Stimulation by odorants and inhibition by Ca2+.大鼠的嗅觉腺苷酸环化酶。气味剂的刺激作用和Ca2+的抑制作用。
Biochem J. 1986 Dec 1;240(2):605-7. doi: 10.1042/bj2400605.
2
Effects of Ca2+ and calmodulin on adenylyl cyclase activity in sheep olfactory epithelium.钙离子和钙调蛋白对绵羊嗅觉上皮中腺苷酸环化酶活性的影响。
Neurochem Res. 1995 Dec;20(12):1511-7. doi: 10.1007/BF00970601.
3
The influence of temperature and membrane-fluidity changes on the olfactory adenylate cyclase of the rat.温度和膜流动性变化对大鼠嗅觉腺苷酸环化酶的影响。
Biochem J. 1987 Jul 15;245(2):613-6. doi: 10.1042/bj2450613.
4
Bovine olfactory cilia preparation: thiol-modulated odorant-sensitive adenylyl cyclase.牛嗅觉纤毛制剂：硫醇调节的气味敏感腺苷酸环化酶。
Biochim Biophys Acta. 1989 Sep 4;1013(1):68-72. doi: 10.1016/0167-4889(89)90129-8.
5
The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants.嗅觉受体细胞的气味敏感腺苷酸环化酶。不同类气味剂的差异刺激。
J Biol Chem. 1986 Nov 25;261(33):15538-43.
6
Ca2(+)-independent stimulation of adenylate cyclase activity by muscarinic receptors in rat olfactory bulb.毒蕈碱受体对大鼠嗅球中腺苷酸环化酶活性的非钙离子依赖性刺激作用
J Neurochem. 1990 Sep;55(3):1083-6. doi: 10.1111/j.1471-4159.1990.tb04603.x.
7
Odorant-sensitive adenylate cyclase: rapid, potent activation and desensitization in primary olfactory neuronal cultures.嗅觉敏感腺苷酸环化酶：原代嗅觉神经元培养物中的快速、强效激活和脱敏
Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2366-9. doi: 10.1073/pnas.88.6.2366.
8
The detergent Solulan C-24 reveals properties of the olfactory adenylate cyclase system.洗涤剂Solulan C-24揭示了嗅觉腺苷酸环化酶系统的特性。
Biochem J. 1989 Jun 15;260(3):683-7. doi: 10.1042/bj2600683.
9
Cytochemical localization of adenylate cyclase activity in rat olfactory cells.大鼠嗅觉细胞中腺苷酸环化酶活性的细胞化学定位
Histochem J. 1991 Feb;23(2):83-90. doi: 10.1007/BF01047112.
10
GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb.γ-氨基丁酸（B）受体介导大鼠嗅球膜中腺苷酸环化酶活性的刺激作用。
Br J Pharmacol. 1999 Feb;126(3):657-64. doi: 10.1038/sj.bjp.0702349.
引用本文的文献
1
High-gain, low-noise amplification in olfactory transduction.嗅觉转导中的高增益、低噪声放大。
Biophys J. 1997 Aug;73(2):1110-7. doi: 10.1016/S0006-3495(97)78143-8.
2
Effects of Ca2+ and calmodulin on adenylyl cyclase activity in sheep olfactory epithelium.钙离子和钙调蛋白对绵羊嗅觉上皮中腺苷酸环化酶活性的影响。
Neurochem Res. 1995 Dec;20(12):1511-7. doi: 10.1007/BF00970601.
3
Gated conductances in native and reconstituted membranes from frog olfactory cilia.来自青蛙嗅觉纤毛的天然膜和重组膜中的门控电导。
Biophys J. 1996 Feb;70(2):813-7. doi: 10.1016/S0006-3495(96)79625-X.
4
Contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the salamander.睫状环核苷酸门控电导对蝾螈嗅觉转导的作用。
J Physiol. 1993 Mar;462:175-96. doi: 10.1113/jphysiol.1993.sp019550.
5
Cytochemical localization of cyclic 3',5'-nucleotide phosphodiesterase activity in the rat olfactory mucosa.大鼠嗅黏膜中3',5'-环核苷酸磷酸二酯酶活性的细胞化学定位
Histochem J. 1993 May;25(5):348-56. doi: 10.1007/BF00159499.
6
R2D5 antigen: a calcium-binding phosphoprotein predominantly expressed in olfactory receptor neurons.R2D5抗原：一种主要在嗅觉受体神经元中表达的钙结合磷蛋白。
J Cell Biol. 1993 Nov;123(4):963-76. doi: 10.1083/jcb.123.4.963.
7
The cyclic nucleotide-activated conductance in olfactory cilia: effects of cytoplasmic Mg2+ and Ca2+.嗅觉纤毛中环状核苷酸激活的电导：细胞质镁离子和钙离子的影响。
J Membr Biol. 1993 Feb;131(3):237-43. doi: 10.1007/BF02260112.
8
Olfactory transduction mechanisms in sheep.绵羊的嗅觉转导机制。
Neurochem Res. 1995 Jun;20(6):719-25. doi: 10.1007/BF01705541.
9
Olfactory transduction is intrinsically noisy.嗅觉转导本质上是有噪声的。
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7864-8. doi: 10.1073/pnas.92.17.7864.
10
Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists.钙调蛋白拮抗剂对嗅觉环核苷酸激活电流的抑制作用。
Br J Pharmacol. 1994 Feb;111(2):469-72. doi: 10.1111/j.1476-5381.1994.tb14760.x.
本文引用的文献
1
Analysis of the electrical activity of the olfactory epithelium.嗅觉上皮电活动分析
Acta Physiol Scand Suppl. 1955;35(122):1-83.
2
Qualitative and quantitative freeze-fracture studies on olfactory and nasal respiratory structures of frog, ox, rat, and dog. I. A general survey.蛙、牛、大鼠和犬嗅觉及鼻呼吸结构的定性和定量冷冻断裂研究。I. 概述。
Cell Tissue Res. 1980;207(2):183-209. doi: 10.1007/BF00237805.
3
Perireceptor and receptor events in vertebrate olfaction.脊椎动物嗅觉中的感受器外周及感受器事件
Prog Neurobiol. 1984;23(4):317-45. doi: 10.1016/0301-0082(84)90008-x.
4
High activity of adenyl cyclase in olfactory and gustatory organs.嗅觉和味觉器官中腺苷酸环化酶的高活性。
Biochem Biophys Res Commun. 1972 Jul 11;48(1):30-4. doi: 10.1016/0006-291x(72)90339-7.
5
Mutiple profile-multiple receptor site model for vertebrate olfaction.脊椎动物嗅觉的多轮廓-多受体位点模型
J Theor Biol. 1973 Aug 22;40(3):469-84. doi: 10.1016/0022-5193(73)90005-2.
6
Determination of protein: a modification of the Lowry method that gives a linear photometric response.蛋白质的测定：一种改进的洛瑞法，可产生线性光度响应。
Anal Biochem. 1972 Aug;48(2):422-7. doi: 10.1016/0003-2697(72)90094-2.
7
Odorant-sensitive adenylate cyclase may mediate olfactory reception.气味敏感型腺苷酸环化酶可能介导嗅觉接收。
Nature. 1985;316(6025):255-8. doi: 10.1038/316255a0.
8
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
9
Evidence for the specific involvement of cyclic AMP in the olfactory transduction mechanism.环磷酸腺苷在嗅觉转导机制中具体参与的证据。
Biochem Biophys Res Commun. 1977 Jul 25;77(2):671-7. doi: 10.1016/s0006-291x(77)80031-4.
10
Cardiac adenosine 3':5'-monophosphate. Free and bound forms in the isolated rat atrium.心脏3':5'-单磷酸腺苷。离体大鼠心房中的游离形式和结合形式
J Biol Chem. 1977 Feb 10;252(3):1041-50.
Zotero 插件