Fernández Lastra C, Mariño E L, Dominguez-Gil A
Arzneimittelforschung. 1986 Oct;36(10):1518-20.
A study was carried out on the access and residence of (-)(1R,2S)-1,2-epoxypropylphosphonic acid (phosphomycin) in interstitial tissue fluid produced experimentally by subcutaneous implantation of spiral steel cages after administration of doses of 20, 30 and 60 mg/kg of the antibiotic to rabbits. The levels reached by the drug in serum and interstitial tissue fluid (ITF) were determined by a microbiological plate diffusion method. The elimination half-lives of phosphomycin ranged between 1.16 and 1.57 h. These values are similar to those found for the disappearance half-lives from ITF. Phosphomycin reached maximum concentrations in ITF between 31.95 and 80.37 micrograms/ml. Linear relationships were established between the (AUC) 0 infinity in serum, the (AUC) 0 infinity in ITF and Cmax in ITF and the doses studied, revealing the non-dose-dependent kinetics of phosphomycin. The linearity of phosphomycin kinetics was checked in serum and ITF by applying the superposition principle.
对家兔分别给予20、30和60mg/kg剂量的抗生素（-）（1R，2S）-1,2-环氧丙基膦酸（磷霉素）后，通过皮下植入螺旋形钢笼产生实验性间质组织液，对磷霉素在该组织液中的进入和留存情况进行了研究。采用微生物平板扩散法测定药物在血清和间质组织液（ITF）中达到的水平。磷霉素的消除半衰期在1.16至1.57小时之间。这些值与从ITF中消失的半衰期值相似。磷霉素在ITF中的最大浓度在31.95至80.37微克/毫升之间。血清中的（AUC）0至无穷大、ITF中的（AUC）0至无穷大以及ITF中的Cmax与所研究的剂量之间建立了线性关系，揭示了磷霉素的非剂量依赖性动力学。通过应用叠加原理，在血清和ITF中检验了磷霉素动力学的线性。
