Dominguez-Gil A A, Garcia M J, Cepeda M, Lanao J M, Dominguez-Gil A
Clin Ther. 1981;3(6):413-24.
The pharmacokinetics of cefoxitin were studied after the administration of a single intravenous dose of 40 mg/kg to rabbits with normal renal function and rabbits with varying degrees of renal impairment. The plasma and interstitial fluid concentrations of the antibiotic were determined by a microbiologic plate diffusion method. The antibiotic follows a two-compartment open kinetic model. The plasma half-life of slow disposition phase t1/2 beta, increases from 0.26 hour in rabbits with normal renal function to 5.41 hours in rabbits with severe renal impairment. In the interstitial fluid the elimination half-life increases from 1.18 hours in rabbits with normal renal function to 99.00 hours in rabbits with renal impairment. A linear relationship is established between the values that define the elimination of the antibiotic and the serum creatinine concentrations. The constant of the incorporation into the interstitial fluid decreases significantly in rabbits with renal impairment.
对肾功能正常的家兔和不同程度肾功能损害的家兔静脉注射单剂量40mg/kg头孢西丁后，研究了其药代动力学。采用微生物平板扩散法测定抗生素的血浆和组织间液浓度。该抗生素遵循二室开放动力学模型。慢处置相的血浆半衰期t1/2β，从肾功能正常的家兔的0.26小时增加到严重肾功能损害家兔的5.41小时。在组织间液中，消除半衰期从肾功能正常家兔的1.18小时增加到肾功能损害家兔的99.00小时。定义抗生素消除的数值与血清肌酐浓度之间建立了线性关系。肾功能损害家兔中进入组织间液的常数显著降低。
