Sirot J, Lopitaux R, Dumont C, Rampon S, Cluzel R
Pathol Biol (Paris). 1983 Jun;31(6):522-4.
Fosfomycine diffusion into spongious and cortical bone was studied in 20 patients undergoing total replacement of the hip after an intravenous infusion of 4 g (1 g/h). The serum and bone samples were collected 1 h and 3 h after administration of the drug. Concentrations at 1 h were 105.0 +/- 12.4 micrograms/ml, 19.6 +/- 4.8 micrograms/g and 13.3 +/- 3.7 micrograms/g in serum, spongious bone and cortical bone respectively; at 3 h these concentrations had become respectively 67.8 +/- 15.9 micrograms/ml, 10.0 +/- 4.2 micrograms/g and 8.2 +/- 3.6 micrograms/g. Antibiotic levels in bone tissue decreased in direct ratio to corresponding serum values, the mean tissue/serum ratio remaining at 15 +/- 4%.
在20例接受全髋关节置换术的患者中，静脉输注4克（1克/小时）磷霉素后，研究了磷霉素在松质骨和皮质骨中的扩散情况。给药后1小时和3小时采集血清和骨样本。给药后1小时，血清、松质骨和皮质骨中的浓度分别为105.0±12.4微克/毫升、19.6±4.8微克/克和13.3±3.7微克/克；3小时时，这些浓度分别变为67.8±15.9微克/毫升、10.0±4.2微克/克和8.2±3.6微克/克。骨组织中的抗生素水平与相应血清值成直接比例下降，平均组织/血清比值保持在15±4%。
