Krell H, Blaich G, Pfaff E
Biol Chem Hoppe Seyler. 1986 Nov;367(11):1153-8. doi: 10.1515/bchm3.1986.367.2.1153.
Ruthenium red-induced calcium efflux from rat liver mitochondria is accelerated in the course of calcium-mediated mitochondrial transition. Analysis of the efflux patterns reveals biexponential kinetics consisting of the native slow phase preceded by a faster phase developing in the presence of calcium. The data are consistent with a progressive transformation of mitochondrial calcium into a rapidly dischargeable pool prior to spontaneous calcium release. Analysis of the efflux pattern is proposed as a method to discriminate between different mechanisms of modulation of ruthenium red-induced calcium efflux. Thus, it is shown that acetate, in contrast to phosphate, stimulates ruthenium red-induced calcium efflux due to the development of the rapidly dischargeable pool of calcium.
钌红诱导的大鼠肝脏线粒体钙外流在钙介导的线粒体转变过程中加速。对流出模式的分析揭示了双指数动力学，包括天然的慢相以及在钙存在下出现的更快相。这些数据与线粒体钙在自发钙释放之前逐渐转化为可快速排出的池相一致。提出对流出模式的分析作为一种区分钌红诱导的钙外流不同调节机制的方法。因此，结果表明，与磷酸盐相反，乙酸盐由于可快速排出的钙池的形成而刺激钌红诱导的钙外流。
