奴泼卡因对大鼠肝线粒体钙外流的作用。
The action of Nupercaine on calcium efflux from rat liver mitochondria.
作者信息
Dawson A P, Fulton D V
出版信息
Biochem J. 1980 Jun 15;188(3):749-55. doi: 10.1042/bj1880749.
Abstract
- Nupercaine inhibits the Ca2+ efflux from rat liver mitochondria observed in the presence of Ruthenium Red, 50% inhibition being obtained at 80 microM-Nupercaine. 2. Neither the Ruthenium Red-stimulated efflux nor its inhibition by Nupercaine can be directly attributed to effects on mitochondrial stability. 3. Nupercaine perturbs the steady-state external Ca2+ concentration in the absence of Ruthenium Red to an extent that is explicable in terms of the inhibition of Ca2+ efflux. 4. Various factors that are likely to be involved in determining steady-state extra-mitochondrial Ca2+ concentrations are discussed.
摘要
- 纽白卡因抑制在钌红存在下观察到的大鼠肝线粒体Ca2+外流，在80微摩尔纽白卡因时获得50%的抑制率。2. 钌红刺激的外流及其被纽白卡因抑制均不能直接归因于对线粒体稳定性的影响。3. 在没有钌红的情况下，纽白卡因会扰乱稳态外部Ca2+浓度，其程度可根据Ca2+外流的抑制来解释。4. 讨论了可能参与确定稳态线粒体外Ca2+浓度的各种因素。
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