2型糖尿病患者腿部肌肉质量指数与非酒精性脂肪性肝病的相关性
The Correlation Between Leg Muscle Mass Index and Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus.
作者信息
Liu Menggege, Zhang Qing, Liu Juan, Bai Huiling, Yang Ping, Ye Xinhua, Yuan Xiaoqing
机构信息
Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, People's Republic of China.
Second Clinical College, Dalian Medical University, Dalian, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2023 Dec 20;16:4169-4177. doi: 10.2147/DMSO.S443329. eCollection 2023.
OBJECTIVE
To analyze the relationship between leg skeletal muscle mass index (LSMI) and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) and the ability of LSMI to predict NAFLD.
METHODS
Two hundred patients with T2DM and NAFLD treated at Changzhou Second People's Hospital Affiliated with Nanjing Medical University and the National Metabolic Management Center from June 2022 to June 2023 were divided into four LSMI quartiles. The clinical information from the four patient groups was compared, and the relationship between type 2 diabetes and LSMI and NAFLD was examined. We used receiver operating characteristic curves to determine how well the LSMI predicts NAFLD in T2DM.
RESULTS
The lowest quartile (Q1) had a higher prevalence of NAFLD than group Q4 ( < 0.05). LSMI was negatively associated with body mass index, LS, CAP, and other markers ( < 0.05). Receiver operating characteristic curve analysis LSMI predicted NAFLD with an ideal critical value of 0.64 and an area under the curve of 70.9%. The combined predictive value of the LSMI and the appendicular skeletal muscle mass index was more significant.
CONCLUSION
Reduced LSMI is associated with NAFLD.
目的
分析2型糖尿病（T2DM）患者腿部骨骼肌质量指数（LSMI）与非酒精性脂肪性肝病（NAFLD）之间的关系以及LSMI预测NAFLD的能力。
方法
选取2022年6月至2023年6月在南京医科大学附属常州第二人民医院和国家代谢管理中心接受治疗的200例T2DM合并NAFLD患者，分为四个LSMI四分位数组。比较四组患者的临床信息，研究2型糖尿病与LSMI及NAFLD之间的关系。采用受试者工作特征曲线确定LSMI对T2DM患者NAFLD的预测能力。
结果
最低四分位数组（Q1）的NAFLD患病率高于Q4组（<0.05）。LSMI与体重指数、LS、CAP及其他指标呈负相关（<0.05）。受试者工作特征曲线分析显示，LSMI预测NAFLD的理想临界值为0.64，曲线下面积为70.9%。LSMI与四肢骨骼肌质量指数的联合预测价值更显著。
结论
LSMI降低与NAFLD相关。
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