Yan Binghan, Li Zhichao, Su Hui, Xue Haipeng, Qiu Daodi, Xu Zhanwang, Tan Guoqing
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Pharmacol. 2023 Dec 7;14:1178310. doi: 10.3389/fphar.2023.1178310. eCollection 2023.
Bone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough medical interventions and the poor understanding of their pathogenesis. Non-coding RNAs (ncRNAs) are heterogeneous transcripts that cannot encode the proteins but can affect the expressions of other genes. Autophagy is a fundamental mechanism for keeping cell viability, recycling cellular contents through the lysosomal pathway, and maintaining the homeostasis of the intracellular environment. There is growing evidence that ncRNAs, autophagy, and crosstalk between ncRNAs and autophagy play complex roles in progression of metabolic bone disease. This review investigated the complex mechanisms by which ncRNAs, mainly micro RNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate autophagic pathway to assist in treating bone metabolism disorders. It aimed at identifying the autophagy role in bone metabolism disorders and understanding the role, potential, and challenges of crosstalk between ncRNAs and autophagy for bone metabolism disorders treatment.
由于缺乏有效且彻底的医学干预措施以及对发病机制的了解不足，骨代谢疾病一直困扰着并仍在折磨着全世界的人们。非编码RNA（ncRNAs）是一类异质性转录本，它们不能编码蛋白质，但可以影响其他基因的表达。自噬是维持细胞活力、通过溶酶体途径循环利用细胞内容物以及维持细胞内环境稳态的一种基本机制。越来越多的证据表明，ncRNAs、自噬以及ncRNAs与自噬之间的相互作用在代谢性骨病的进展中发挥着复杂的作用。本综述研究了ncRNAs（主要是微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs））调节自噬途径以辅助治疗骨代谢紊乱的复杂机制。其目的是确定自噬在骨代谢紊乱中的作用，并了解ncRNAs与自噬之间的相互作用在骨代谢紊乱治疗中的作用、潜力和挑战。
