Gao Jinning, Chen Xiatian, Shan Chan, Wang Yin, Li Peifeng, Shao Kai
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China.
Department of Central Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong 266035, China.
Mol Ther Nucleic Acids. 2020 Nov 4;23:101-118. doi: 10.1016/j.omtn.2020.10.039. eCollection 2021 Mar 5.
Cardiovascular diseases (CVDs) remain the world's leading cause of death. Cardiomyocyte autophagy helps maintain normal metabolism and functioning of the heart. Importantly, mounting evidence has revealed that autophagy plays a dual role in CVD pathology. Under physiological conditions, moderate autophagy maintains cell metabolic balance by degrading and recycling damaged organelles and proteins, and it promotes myocardial survival, but excessive or insufficient autophagy is equally deleterious and contributes to disease progression. Noncoding RNAs (ncRNAs) are a class of RNAs transcribed from the genome, but most ncRNAs do not code for functional proteins. In recent years, increasingly, various ncRNAs have been identified, and they play important regulatory roles in the physiological and pathological processes of organisms, as well as in autophagy. Thus, determining whether ncRNA-regulated autophagy plays a protective role in CVDs or promotes their progression can help us to develop ncRNAs as therapeutic targets in autophagy-related CVDs. In this review, we briefly summarize the regulatory roles of several important ncRNAs, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the autophagy of various CVDs to provide a theoretical basis for the etiology and pathogenesis of CVDs and develop novel therapies to treat CVDs.
心血管疾病（CVDs）仍然是全球首要的死亡原因。心肌细胞自噬有助于维持心脏的正常代谢和功能。重要的是，越来越多的证据表明自噬在心血管疾病病理学中发挥双重作用。在生理条件下，适度的自噬通过降解和循环利用受损的细胞器和蛋白质来维持细胞代谢平衡，并促进心肌存活，但过度或不足的自噬同样有害，并会导致疾病进展。非编码RNA（ncRNAs）是一类从基因组转录而来的RNA，但大多数ncRNAs并不编码功能性蛋白质。近年来，越来越多的各种ncRNAs被鉴定出来，它们在生物体的生理和病理过程以及自噬中发挥重要的调节作用。因此，确定ncRNA调控的自噬在心血管疾病中是起到保护作用还是促进其进展，有助于我们将ncRNAs开发为自噬相关心血管疾病的治疗靶点。在本综述中，我们简要总结了几种重要的ncRNAs，包括微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），在各种心血管疾病自噬中的调控作用，为心血管疾病的病因和发病机制提供理论依据，并开发治疗心血管疾病的新疗法。
