Shamkulashvili G G, Dumbadze G G, Nanobashvili N D, Mchedlishvili T V, Papava M V
Biokhimiia. 1987 Jan;52(1):37-41.
The changes in the oxidative metabolism of rabbit myocardium in hemorrhagic shock were studied. The external pathway of NADH oxidation was shown to be activated, while the rates of glutamate oxidation in the presence of an uncoupler were diminished as compared to control values. These changes are probably due to the activation of phospholipase A2 and lipid peroxidation, since their inhibitors eliminate with the same efficiency the activation of the external pathway of NADH oxidation both in normal and damaged myocardium.
研究了兔心肌在失血性休克时氧化代谢的变化。结果表明，NADH氧化的外部途径被激活，而与对照值相比，在解偶联剂存在下谷氨酸氧化速率降低。这些变化可能是由于磷脂酶A2的激活和脂质过氧化，因为它们的抑制剂能以相同的效率消除正常和受损心肌中NADH氧化外部途径的激活。
