Shrivastava Ankur K, Bodhey Narendra Kuber, Patial Yamini, Pati Saroj K
Ophthalmology, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Radiodiagnosis, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Cureus. 2023 Nov 25;15(11):e49388. doi: 10.7759/cureus.49388. eCollection 2023 Nov.
A 55-year-old female was referred to the Department of Ophthalmology with complaints of bilateral loss of vision. She had undergone subtotal gastrectomy with gastrojejunostomy and lymphadenectomy for poorly differentiated gastric adenocarcinoma in the antropyloric region the day before. On the first postoperative day, she complained of generalised weakness, drowsiness, altered sensorium, and acute, painless, bilateral loss of vision. Ocular examination revealed visual acuity as no perception of light, bilaterally, and normal pupillary light reflexes. Anterior and posterior segment examination was within normal limits. This clinical presentation of altered sensorium and cortical blindness along with characteristic radiological findings (hyperintensity on T2/fluid-attenuated inversion recovery sequence involving the bilateral parieto-occipital lobe extending in asymmetric fashion to the bilateral cerebellum, brainstem, and thalami predominantly involving the white matter with few areas of diffusion restriction on diffusion-weighted imaging sequence predominantly on the left side with gyriform pattern) confirmed the diagnosis of posterior reversible encephalopathy syndrome (PRES). In cancer patients, PRES has been reported in patients on chemotherapy regimen or two weeks after surgery for gastric cancer. Here, we want to draw attention to the fact that PRES may develop in the immediate postoperative period of gastric cancer surgery, as seen in our case.
一名55岁女性因双侧视力丧失被转诊至眼科。她在前一天因胃窦部低分化胃腺癌接受了胃大部切除术、胃空肠吻合术和淋巴结清扫术。术后第一天,她主诉全身无力、嗜睡、意识改变以及急性、无痛性双侧视力丧失。眼部检查显示双侧视力均无光感,瞳孔对光反射正常。眼前段和后段检查均在正常范围内。这种意识改变和皮质盲的临床表现以及特征性的影像学表现(T2加权/液体衰减反转恢复序列上双侧顶枕叶高信号,不对称地延伸至双侧小脑、脑干和丘脑,主要累及白质,弥散加权成像序列上左侧有少数弥散受限区域,呈脑回样分布)确诊为后部可逆性脑病综合征(PRES)。在癌症患者中,PRES已在接受化疗方案的患者或胃癌手术后两周的患者中被报道。在此,我们想提请注意,如我们的病例所示,PRES可能在胃癌手术后的即刻发生。