Sela J, Applebaum J, Uretzky G
Biomater Med Devices Artif Organs. 1986;14(3-4):227-37. doi: 10.3109/10731198609117544.
This study was designed to examine the effect of inflammatory reaction elicited by percutaneous tube on bone induction. Inflammation was provoked by different types of biomaterials. In order to evaluate incorporation of percutaneous tubes, bone matrix and subcutaneous tissue, demineralizing bone matrix was implanted in the subcutaneous tissue of rats and was exposed to interaction with inflammatory conditions. Inhibition to the induction of cartilage and bone by the inflammatory process could be clearly demonstrated. It is suggested that the low pH levels, typical to enzymes operative in inflammation are a direct cause for inhibition of chondro and osteogenesis. The process of calcification is characterized by the activation of enzymes in high pH levels.
本研究旨在探讨经皮导管引发的炎症反应对骨诱导的影响。炎症由不同类型的生物材料诱发。为了评估经皮导管、骨基质和皮下组织的融合情况，将脱矿骨基质植入大鼠皮下组织，并使其暴露于炎症条件下相互作用。炎症过程对软骨和骨诱导的抑制作用可得到明确证实。有人认为，炎症中起作用的酶所特有的低pH水平是软骨生成和骨生成受抑制的直接原因。钙化过程的特征是高pH水平下酶的激活。
