Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Mol Imaging Biol. 2024 Apr;26(2):222-232. doi: 10.1007/s11307-023-01888-5. Epub 2023 Dec 26.
Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research and applications with in vivo MR imaging and spectroscopy (MRI/S). Hyperpolarized C MRI/S, in particular, enables real-time non-invasive assessment of metabolic processes and holds great promise for a diverse range of clinical applications spanning fields like oncology, neurology, and cardiology, with a potential for improving early diagnosis of disease, patient stratification, and therapy response assessment. Despite its potential, technical challenges remain for achieving clinical translation. This paper provides an overview of the discussions that took place at the international workshop "New Horizons in Hyperpolarized C MRI," in March 2023 at the Bavarian Academy of Sciences and Humanities, Munich, Germany. The workshop covered new developments, as well as future directions, in topics including polarization techniques (particularly focusing on parahydrogen-based methods), novel probes, considerations related to data acquisition and analysis, and emerging clinical applications in oncology and other fields.
极化技术极大地提高了磁共振（MR）的灵敏度，从而为活体磁共振成像和光谱学（MRI/S）的研究和应用带来了令人兴奋的新方向。特别是，极化 C 的 MRI/S 能够实时非侵入性地评估代谢过程，在肿瘤学、神经病学和心脏病学等多个临床领域具有广泛的应用前景，有望改善疾病的早期诊断、患者分层和治疗反应评估。尽管具有潜力，但在实现临床转化方面仍存在技术挑战。本文概述了 2023 年 3 月在德国慕尼黑巴伐利亚科学院举行的“极化 C 的 MRI 新视野”国际研讨会的讨论情况。该研讨会涵盖了极化技术（特别是侧重于基于副氢的方法）、新型探针、与数据采集和分析相关的考虑因素以及肿瘤学和其他领域新兴临床应用等主题的新进展和未来方向。
