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[适应新环境及建立被动回避条件反射后不同年龄大鼠脑内去甲肾上腺素含量]

[Noradrenaline content of the brain of rats of various ages following adaptation to a new situation and to the development of a passive avoidance conditioned reflex].

作者信息

Kulikova N A, Kassil' V G

出版信息

Biull Eksp Biol Med. 1987 Feb;103(2):136-8.

PMID:3814786
Abstract

Noradrenaline (NA) levels in cortico-striatal (including cerebral cortex, hippocamp, striatum) and hypothalamo-brainstem (including hypothalamus, thalamus, tectum + tegmentum) regions were determined by fluorometry in I- and 2-month-old male rats after 7-day adaptation to experimental conditions and passive avoidance learning by single electric foot shock. Neither the new environment nor a week's adaptation to it resulted in any significant alteration of NA content in both brain regions of 1- and 2-month-old rats. No considerable differences in NA levels were found in rats of both age groups with and without passive avoidance responses. But 24 hours after the exposure to foot shock NA basal levels markedly decreased in both brain regions of 1-month-old rats, while in 2-month-old ones NA basal levels markedly increased in hypothalamo-brainstem region.

摘要

在1月龄和2月龄雄性大鼠适应实验条件7天并通过单次电足电击进行被动回避学习后,采用荧光测定法测定其皮质纹状体(包括大脑皮层、海马、纹状体)和下丘脑脑干(包括下丘脑、丘脑、顶盖 + 被盖)区域的去甲肾上腺素(NA)水平。新环境及其一周的适应期均未导致1月龄和2月龄大鼠这两个脑区的NA含量发生任何显著变化。在有和没有被动回避反应的两个年龄组大鼠中,未发现NA水平有显著差异。但是,在遭受足电击24小时后,1月龄大鼠的两个脑区NA基础水平均显著降低,而2月龄大鼠下丘脑脑干区域的NA基础水平则显著升高。

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