Kulikova N A, Kassil' V G
Biull Eksp Biol Med. 1982 Apr;93(4):6-7.
Fluorometry was used to determine the content of 11-hydroxycorticosteroids (11-HCS) in the blood plasma of 2-month-old male rats in the course of passive avoidance learning by means of single electrocutaneous irritation (ECI) of the limbs. Pre-exposure of the animals for 7 days to experimental environment (over 3 min daily) led to a distinct reduction of the basal content of 11-HCS which returned to the initial level after adaptation discontinuance. One day after ECI the content of 11-HCS in rats which learned passive avoidance, was appreciably lower as compared to that in the animals which failed to learn the behavioral task. Five days after ECI the differences in the content of the corticosteroids in the animals of the two groups were little pronounced. It appears that while using passive avoidance as a long-term memory model, account should be taken of both the behavioral and emotional responses.
采用荧光测定法，通过对2月龄雄性大鼠的四肢进行单次电皮肤刺激（ECI），在被动回避学习过程中测定其血浆中11-羟基皮质类固醇（11-HCS）的含量。将动物预先暴露于实验环境7天（每天超过3分钟），导致11-HCS的基础含量明显降低，在停止适应后恢复到初始水平。在ECI后一天，学会被动回避的大鼠体内11-HCS的含量明显低于未学会行为任务的动物。ECI后五天，两组动物体内皮质类固醇含量的差异不太明显。看来，在将被动回避作为长期记忆模型时，应同时考虑行为和情绪反应。
