Kulikova N A, Kassil' V G
Biull Eksp Biol Med. 1984 Jun;97(6):645-7.
Plasma 11-hydroxycorticosteroid (11-OHCS) levels were measured in 30-day-old rats by fluorometry during passive avoidance (PA) learning by means of a single electric footshock. In contrast to the data obtained in adult animals, pre-exposure of young rats for 7 days to the experimental environment (over 3 min daily) resulted in elevation of the basal 11-OHCS levels and in the lack of distinct changes in the hormonal background after placing the young rats into a chamber. As in previous experiments on adult rats, one day after PA learning the 11-OHCS levels were significantly lower in young rats displaying PA than in the animals which did not exhibit PA behavior. Five days after PA training these differences in adrenocortical reactivity disappeared, as was the case in adult animals.
通过荧光法测量了30日龄大鼠在单次电击足底被动回避（PA）学习过程中的血浆11-羟皮质类固醇（11-OHCS）水平。与成年动物的数据相反，幼鼠在实验环境中预暴露7天（每天超过3分钟）会导致基础11-OHCS水平升高，并且幼鼠被放入实验箱后激素背景没有明显变化。与之前对成年大鼠的实验一样，在PA学习一天后，表现出PA的幼鼠的11-OHCS水平显著低于未表现出PA行为的动物。与成年动物一样，在PA训练五天后，肾上腺皮质反应性的这些差异消失了。
