Ashmarin I P, Syracheva N Iu, Vlasova T I, Kalikhevich V N, Kamenskiĭ A A
Biull Eksp Biol Med. 1987 Feb;103(2):178-81.
Tetrapeptide tuftsin in doses adapted to its physiological blood concentrations partially normalized locomotor activity and orientation behaviour of rats altered by drugs affecting aminergic brain systems. At the same time tuftsin had no effect when applied after the treatment by dopaminergic drugs (DTC, haloperidol, apomorphine). It can be concluded that the central effect observed in the first minutes after tuftsin administration is mediated through dopaminergic system. Elimination of some drug-induced behavioural disturbances by tuftsin opens new prospects for its therapeutic application.
剂量与生理血药浓度相适应的四肽促吞噬素能部分使受影响胺能脑系统的药物改变的大鼠运动活动和定向行为恢复正常。同时，在多巴胺能药物（二硫代氨基甲酸盐、氟哌啶醇、阿扑吗啡）治疗后应用促吞噬素则没有效果。可以得出结论，促吞噬素给药后最初几分钟观察到的中枢效应是通过多巴胺能系统介导的。促吞噬素消除一些药物引起的行为障碍为其治疗应用开辟了新前景。
