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四肽塔夫辛的精神药物特性及其对学习的影响

[Psychotropic properties of the tetrapeptide taftsin and its effect on learning].

作者信息

Lavretskaia E F, Ashmarin I P, Kamenskiĭ A A, Chamorovskaia L T, Antonova L V

出版信息

Farmakol Toksikol. 1981 May-Jun;44(3):275-9.

PMID:6895197
Abstract

Experiments on mice and rats have disclosed that taftsin so far known for its stimulatory action on phagocytosis has psychotropic properties. Taftsin potentiates the motor and orienting activity of the animals, reduces the effects of hexenal, reserpine, potentiates the action of amphetamine and arecoline. It shortens the latent period and time of the reaction during training of the rats in a T-shaped maze, but does not increase the number of the training animals. The effect of taftsin has a biphasic nature and seems likely to be related to the effect on alpha-adrenergic systems of the brain.

摘要

对小鼠和大鼠的实验表明,迄今以其对吞噬作用的刺激作用而闻名的塔夫辛具有精神otropic特性。塔夫辛增强动物的运动和定向活动,减轻己烯醛、利血平的作用,增强苯丙胺和槟榔碱的作用。它缩短了大鼠在T形迷宫训练期间反应的潜伏期和时间,但不会增加训练动物的数量。塔夫辛的作用具有双相性,似乎与对大脑α-肾上腺素能系统的作用有关。

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