[Effect of tuftsin on the orientation-exploratory behavior of normal white rats and against a background of pharmacologically induced disorders of the brain biogenic amine system].

The application of "hole board" method showed that the endogenic immunostimulator tetrapeptide tuftsin injected intraperitoneally in dose 0.3 mg/kg has a short-time stimulating action on the orienting reaction of rats in 5 min, though in 24 hours it suppresses the registered behavioral indexes. The pharmacological analysis of the above studied phenomenon showed that catecholaminergic and especially dopaminergic brain systems played the leading role in tuftsin effect. Tuftsin can normalize animals' behaviour disturbed by the pharmacological agents, which slightly influence the functioning of the brain dopaminergic system.