Valenzuela Xavier, Hedman Hayden, Villagomez Alma, Cardenas Paul, Eisenberg Joseph N S, Levy Karen, Zhang Lixin, Trueba Gabriel
Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador.
Facultad de Medicina, Universidad de la Americas (UDLA), Quito, Ecuador.
Med Microecol. 2023 Dec;18. doi: 10.1016/j.medmic.2023.100092. Epub 2023 Oct 31.
The increasing abundance of extended spectrum (β-lactamase (ESBL) genes in , and other commensal and pathogenic bacteria, endangers the utility of third or more recent generation cephalosporins, which are major tools for fighting deadly infections. The role of domestic animals in the transmission of ESBL carrying bacteria has been recognized, especially in low- and middle-income countries, however the horizontal gene transfer of these genes is difficult to assess. Here we investigate gene diversity (and flanking nucleotide sequences) in from chicken and humans, in an Ecuadorian rural community and from chickens in another location in Ecuador. The associated sequences in isolates from humans and chickens in the same remote community showed greater similarity than those found in in a chicken industrial operation 200 km away. Our study may provide evidence of transfer between chickens and humans in the community.
超广谱β-内酰胺酶（ESBL）基因在大肠杆菌及其他共生菌和病原菌中的丰度不断增加，危及第三代或更新一代头孢菌素的效用，而这些头孢菌素是对抗致命感染的主要工具。家畜在携带ESBL细菌传播中的作用已得到认可，尤其是在低收入和中等收入国家，然而这些基因的水平基因转移很难评估。在此，我们调查了厄瓜多尔一个农村社区鸡和人类以及厄瓜多尔另一个地方鸡体内大肠杆菌的基因多样性（及其侧翼核苷酸序列）。同一偏远社区人类和鸡分离株中相关序列的相似性高于200公里外一家养鸡场大肠杆菌中的序列。我们的研究可能为该社区鸡和人类之间的大肠杆菌转移提供证据。
