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用于皮肤伤口愈合的活性氧清除材料:进展与应用

ROS-scavenging materials for skin wound healing: advancements and applications.

作者信息

Dong Yongkang, Wang Zheng

机构信息

Department of Vascular Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.

Department of Spine Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.

出版信息

Front Bioeng Biotechnol. 2023 Dec 12;11:1304835. doi: 10.3389/fbioe.2023.1304835. eCollection 2023.

Abstract

The intricate healing process of skin wounds includes a variety of cellular and molecular events. Wound healing heavily relies on reactive oxygen species (ROS), which are essential for controlling various processes, including inflammation, cell growth, angiogenesis, granulation, and the formation of extracellular matrix. Nevertheless, an overabundance of reactive oxygen species (ROS) caused by extended oxidative pressure may result in the postponement or failure of wound healing. It is crucial to comprehend the function of reactive oxygen species (ROS) and create biomaterials that efficiently eliminate ROS to enhance the healing process of skin wounds. In this study, a thorough examination is presented on the role of reactive oxygen species (ROS) in the process of wound healing, along with an exploration of the existing knowledge regarding biomaterials employed for ROS elimination. In addition, the article covers different techniques and substances used in the management of skin wound. The future prospects and clinical applications of enhanced biomaterials are also emphasized, highlighting the potential of biomaterials that scavenge active oxygen to promote skin repair. This article seeks to enhance the understanding of the complex processes of ROS in the healing of wounds and the application of ROS-scavenging materials. Its objective is to create novel strategies for effective treatment skin wounds.

摘要

皮肤伤口复杂的愈合过程包括多种细胞和分子事件。伤口愈合严重依赖活性氧(ROS),活性氧对于控制包括炎症、细胞生长、血管生成、肉芽形成和细胞外基质形成在内的各种过程至关重要。然而,长期氧化压力导致的活性氧过量可能会导致伤口愈合延迟或失败。理解活性氧的功能并制造能有效清除活性氧的生物材料对于促进皮肤伤口愈合过程至关重要。在本研究中,全面探讨了活性氧在伤口愈合过程中的作用,同时探索了关于用于清除活性氧的生物材料的现有知识。此外,本文涵盖了用于皮肤伤口处理的不同技术和物质。还强调了增强型生物材料的未来前景和临床应用,突出了清除活性氧以促进皮肤修复的生物材料的潜力。本文旨在增进对活性氧在伤口愈合中的复杂过程以及活性氧清除材料应用的理解。其目标是制定有效治疗皮肤伤口的新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/418f/10749972/4e59237bf2fe/fbioe-11-1304835-g001.jpg

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