介导豚鼠嗅皮层神经元M电流抑制的毒蕈碱受体可能属于M2亚型。
Muscarinic receptors mediating suppression of the M-current in guinea-pig olfactory cortex neurones may be of the M2-subtype.
作者信息
Constanti A, Sim J A
出版信息
Br J Pharmacol. 1987 Jan;90(1):3-5. doi: 10.1111/j.1476-5381.1987.tb16818.x.
Abstract
Guinea-pig olfactory cortical neurones in vitro were voltage clamped by means of a single intracellular microelectrode technique. Hyperpolarizing voltage commands from holding potentials between -40 to -50 mV produced slow inward current relaxations reflecting deactivation of the M-current (IM). IM was reversibly suppressed by 30 microM muscarine or carbachol; this suppression was insensitive to pirenzepine (up to 300 nM) but was inhibited by gallamine (10-20 microM) or 4-diphenyl-acetoxy-N-methylpiperidine (100, 500 nM), suggesting the involvement of the M2-type muscarinic receptor.
摘要
采用单根细胞内微电极技术对体外培养的豚鼠嗅觉皮层神经元进行电压钳制。从-40至-50 mV的钳制电位施加超极化电压指令，可产生缓慢的内向电流松弛，这反映了M电流（IM）的失活。30 μM的毒蕈碱或卡巴胆碱可可逆性抑制IM；这种抑制作用对哌仑西平（高达300 nM）不敏感，但可被加拉明（10 - 20 μM）或4 - 二苯基乙酰氧基 - N - 甲基哌啶（100、500 nM）抑制，提示M2型毒蕈碱受体参与其中。
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