Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2023 Dec 12;14:1301074. doi: 10.3389/fimmu.2023.1301074. eCollection 2023.
Regulatory T cells (Tregs) can eliminate autoreactive lymphocytes, induce self-tolerance, and suppress the inflammatory response. Mitochondria, as the energy factories of cells, are essential for regulating the survival, differentiation, and function of Tregs. Studies have shown that patients with autoimmune diseases of the central nervous system, such as multiple sclerosis, neuromyelitis optica spectrum disorder, and autoimmune encephalitis, have aberrant Tregs and mitochondrial damage. However, the role of mitochondrial-regulated Tregs in autoimmune diseases of the central nervous system remains inconclusive. Therefore, this study reviews the mitochondrial regulation of Tregs in autoimmune diseases of the central nervous system and investigates the possible mitochondrial therapeutic targets.
调节性 T 细胞（Tregs）可以消除自身反应性淋巴细胞，诱导自身耐受，并抑制炎症反应。线粒体作为细胞的能量工厂，对于调节 Tregs 的存活、分化和功能至关重要。研究表明，多发性硬化症、视神经脊髓炎谱系疾病和自身免疫性脑炎等中枢神经系统自身免疫性疾病患者存在异常的 Tregs 和线粒体损伤。然而，线粒体调节的 Tregs 在中枢神经系统自身免疫性疾病中的作用尚不清楚。因此，本研究综述了 Tregs 在线粒体调节中枢神经系统自身免疫性疾病中的作用，并探讨了可能的线粒体治疗靶点。
