Fang Tianxiang, Wang Xizhi, Huangfu Ning
Health Science Center, Ningbo University, Ningbo, China.
Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Front Cardiovasc Med. 2023 Dec 13;10:1309491. doi: 10.3389/fcvm.2023.1309491. eCollection 2023.
Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally. Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic acid (NA) metabolism across various organisms. They play a pivotal role in gene expression, inflammatory response, lipid metabolism, and so forth. However, abnormal helicase expression has been associated with immune response, cancer, and intellectual disability in humans. Superfamily II (SFII) is one of the largest and most diverse of the helicase superfamilies. Increasing evidence has implicated SFⅡ helicases in the pathogenesis of multiple CVDs. In this review, we comprehensively review the regulation mechanism of SFⅡ helicases in CVDs including atherosclerosis, myocardial infarction, cardiomyopathies, and heart failure, which will contribute to the investigation of ideal therapeutic targets for CVDs.
心血管疾病（CVDs）在全球范围内仍保持着较高的发病率和死亡率。解旋酶是一类独特的酶，广泛参与各种生物体的核酸（NA）代谢过程。它们在基因表达、炎症反应、脂质代谢等方面发挥着关键作用。然而，解旋酶表达异常与人类的免疫反应、癌症和智力残疾有关。超家族II（SFII）是最大且最多样化的解旋酶超家族之一。越来越多的证据表明SFⅡ解旋酶与多种心血管疾病的发病机制有关。在这篇综述中，我们全面回顾了SFⅡ解旋酶在包括动脉粥样硬化、心肌梗死、心肌病和心力衰竭在内的心血管疾病中的调节机制，这将有助于研究心血管疾病理想的治疗靶点。
