低剂量氨鲁米特对绝经后Ⅰ期乳腺癌患者自然杀伤细胞活性的调节作用
Modulation of natural killer cell activity in stage I postmenopausal breast cancer patients on low-dose aminoglutethimide.
作者信息
Berry J, Green B J, Matheson D S
出版信息
Cancer Immunol Immunother. 1987;24(1):72-5. doi: 10.1007/BF00199836.
Abstract
Natural killer (NK) cells are important in surveillance against malignant cells. The activity of NK cells can be modulated by naturally occurring mediators; interferon, interleukin-2, and hormones. Low-dose aminoglutethimide (Ag 250 mg/day) inhibits the peripheral aromatization of androstenedione hence decreasing circulating estrogens. Of ten patients treated, seven were evaluable. There was a statistically significant increase in NK activity (P = 0.0025) following the administration of Ag. There was no consistent shift in NK cell number (Leu-11b positive cells). In vitro Ag did not alter NK activity whereas 17-beta-estradiol did. These data are consistent with an indirect effect of Ag on NK activity. Hence in vivo Ag which causes a reduction in serum estrogens in postmenopausal patients, also induces an increase in NK activity.
摘要
自然杀伤（NK）细胞在监测恶性细胞方面很重要。NK细胞的活性可由天然存在的介质调节，如干扰素、白细胞介素-2和激素。低剂量氨鲁米特（Ag，250毫克/天）可抑制雄烯二酮的外周芳香化，从而降低循环雌激素水平。在接受治疗的10名患者中，7名可进行评估。服用Ag后，NK活性有统计学意义的增加（P = 0.0025）。NK细胞数量（Leu-11b阳性细胞）没有一致的变化。体外实验中，Ag不会改变NK活性，而17-β-雌二醇会改变。这些数据与Ag对NK活性的间接作用一致。因此，在体内能使绝经后患者血清雌激素降低的Ag，也会诱导NK活性增加。
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