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一种单克隆抗体，可检测到一种分子量为39,000的分子，该分子存在于B淋巴细胞和慢性淋巴细胞白血病细胞上，但在急性淋巴细胞白血病原始细胞上很少见。

A monoclonal antibody detecting a 39,000 m.w. molecule that is present on B lymphocytes and chronic lymphocytic leukemia cells but is rare on acute lymphocytic leukemia blasts.

作者信息

Zipf T F, Lauzon G J, Longenecker B M

出版信息

J Immunol. 1983 Dec;131(6):3064-72.

PMID:6358359
Abstract

Monoclonal antibody 41H.16 was produced by using the hybridoma methodology in the mouse system with cells from a patient with hairy cell leukemia as the immunogen. This antibody reacts with the majority of Slg+ cells in the peripheral blood and with all B lymphoblastoid cell lines. Reactivity with conventional Ig determinants, Fc or C3 receptors, has been excluded. The antibody reacted with cells from 68 patients with CLL but showed no reactivity with cells in 69 specimens from patients with non-T, non-B ALL. The apparent m.w. of the antigen detected by this antibody is approximately 39,000.

摘要

单克隆抗体41H.16是采用杂交瘤技术在小鼠系统中制备的，以一名毛细胞白血病患者的细胞作为免疫原。该抗体与外周血中的大多数表面免疫球蛋白阳性（Slg+）细胞以及所有B淋巴母细胞系发生反应。已排除其与传统免疫球蛋白决定簇、Fc或C3受体的反应性。该抗体与68例慢性淋巴细胞白血病（CLL）患者的细胞发生反应，但与69例非T、非B急性淋巴细胞白血病（ALL）患者标本中的细胞无反应。该抗体检测到的抗原表观分子量约为39,000。

相似文献

1
A monoclonal antibody detecting a 39,000 m.w. molecule that is present on B lymphocytes and chronic lymphocytic leukemia cells but is rare on acute lymphocytic leukemia blasts.一种单克隆抗体，可检测到一种分子量为39,000的分子，该分子存在于B淋巴细胞和慢性淋巴细胞白血病细胞上，但在急性淋巴细胞白血病原始细胞上很少见。
J Immunol. 1983 Dec;131(6):3064-72.
2
A unique antigen expressed on myeloid cells and acute leukemia blast cells defined by a monoclonal antibody.一种由单克隆抗体定义的、在髓系细胞和急性白血病原始细胞上表达的独特抗原。
J Immunol. 1983 Jun;130(6):2937-41.
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Identification of several cell surface proteins of non-T, non-B acute lymphoblastic leukemia by using monoclonal antibodies.利用单克隆抗体鉴定非T、非B急性淋巴细胞白血病的几种细胞表面蛋白
J Immunol. 1985 Feb;134(2):1276-85.
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Identification of a human endothelial cell antigen with monoclonal antibody 44G4 produced against a pre-B leukemic cell line.利用针对前B淋巴细胞白血病细胞系产生的单克隆抗体44G4鉴定一种人类内皮细胞抗原。
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Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.由单克隆抗体定义的人类T细胞抗原：T细胞的65000道尔顿抗原（T65）也存在于带有表面免疫球蛋白的慢性淋巴细胞白血病细胞上。
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Reactivity of acute lymphoblastic leukemia and normal bone marrow cells with the monoclonal anti-B-lymphocyte antibody, anti-Y 29/55.急性淋巴细胞白血病和正常骨髓细胞与单克隆抗B淋巴细胞抗体抗-Y 29/55的反应性
Cancer Res. 1983 Sep;43(9):4483-5.
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Monoclonal antibody SN2 defining a human T cell leukemia-associated cell surface glycoprotein.定义一种人类T细胞白血病相关细胞表面糖蛋白的单克隆抗体SN2。
J Immunol. 1984 Apr;132(4):2089-95.
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Monoclonal antibody against a unique antigen on human acute promyelocytic leukemia cell line (HL-60).针对人急性早幼粒细胞白血病细胞系（HL-60）上一种独特抗原的单克隆抗体。
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Monoclonal antibody against a membrane antigen characterizing leukemic human B-lymphocytes.针对表征白血病人类B淋巴细胞的膜抗原的单克隆抗体。
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Cellular distribution of a B-cell specific surface antigen (gp54) detected by a monoclonal antibody (anti-BL4).通过单克隆抗体（抗BL4）检测到的B细胞特异性表面抗原（gp54）的细胞分布。
Cancer Res. 1986 Oct;46(10):5431-7.

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Ann Hematol. 1993 Dec;67(6):277-84. doi: 10.1007/BF01696347.
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Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients.多发性骨髓瘤患者外周血中B淋巴细胞严重缺乏。
J Clin Invest. 1984 Oct;74(4):1301-6. doi: 10.1172/JCI111540.
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