Department of Neurology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei 230000, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230000, China.
Biomed Pharmacother. 2024 Jan;170:116066. doi: 10.1016/j.biopha.2023.116066. Epub 2023 Dec 28.
Rheumatoid arthritis (RA) is a multifaceted autoimmune disease characterized by systemic inflammation, affecting both articular and extra-articular structures. This condition results in inflammation of joints and synovial membranes, accompanied by the development of systemic comorbidities. Despite extensive research, the precise pathogenic mechanisms responsible for RA have yet to be completely understood. RNA methylation, a burgeoning epigenetic alteration, assumes a pivotal function in the regulation of a myriad of biological phenomena, encompassing immunity, DNA damage response, tumorigenesis, metastasis, stem cell renewal, adipocyte differentiation, circadian rhythms, cellular development and differentiation, and cell division. The N6-methyladenosine (m6A) modification is the most prevalent among the various RNA modifications found in mammalian mRNA. Recent studies have provided evidence of the significant role played by m6A modification in the pathophysiological progression of RA. This review aims to provide a comprehensive analysis of the progress made in research focused on m6A modification in the context of RA, consolidate the underlying mechanisms involved in m6A modification during the initiation of RA and discuss the potential of targeting m6A modification as a viable therapeutic approach for RA.
类风湿关节炎（RA）是一种多方面的自身免疫性疾病，以全身炎症为特征，影响关节和关节外结构。这种情况会导致关节和滑膜炎症，并伴有全身合并症的发展。尽管进行了广泛的研究，但导致 RA 的精确发病机制仍未完全理解。RNA 甲基化是一种新兴的表观遗传改变，在调节包括免疫、DNA 损伤反应、肿瘤发生、转移、干细胞更新、脂肪细胞分化、昼夜节律、细胞发育和分化以及细胞分裂在内的多种生物学现象中发挥着关键作用。N6-甲基腺苷（m6A）修饰是哺乳动物 mRNA 中发现的各种 RNA 修饰中最常见的一种。最近的研究证据表明，m6A 修饰在 RA 的病理生理进展中起着重要作用。本综述旨在全面分析 RA 中 m6A 修饰研究的进展，整合 RA 起始时 m6A 修饰涉及的潜在机制，并讨论靶向 m6A 修饰作为 RA 可行治疗方法的潜力。
