微生物感染性疾病中的细胞焦亡
Pyroptosis in microbial infectious diseases.
作者信息
Xiao Cui, Cao Saihong, Li Yunfei, Luo Yuchen, Liu Jian, Chen Yuyu, Bai Qinqin, Chen Lili
机构信息
Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Yiyang Medical College, School of Public Health and Laboratory Medicine, Yiyang, Hunan, 421000, China.
出版信息
Mol Biol Rep. 2023 Dec 29;51(1):42. doi: 10.1007/s11033-023-09078-w.
Pyroptosis is a gasdermins-mediated programmed cell death that plays an essential role in immune regulation, and its role in autoimmune disease and cancer has been studied extensively. Increasing evidence shows that various microbial infections can lead to pyroptosis, associated with the occurrence and development of microbial infectious diseases. This study reviews the recent advances in pyroptosis in microbial infection, including bacterial, viral, and fungal infections. We also explore potential therapeutic strategies for treating microbial infection-related diseases by targeting pyroptosis.
细胞焦亡是一种由gasdermin介导的程序性细胞死亡，在免疫调节中起重要作用，其在自身免疫性疾病和癌症中的作用已得到广泛研究。越来越多的证据表明，各种微生物感染可导致细胞焦亡，这与微生物感染性疾病的发生和发展有关。本研究综述了微生物感染中细胞焦亡的最新进展，包括细菌、病毒和真菌感染。我们还探讨了通过靶向细胞焦亡治疗微生物感染相关疾病的潜在治疗策略。
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