Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Huazhong University of Science and Technology, Ministry of Education, Chinese Academy of Medical Sciences, 1095 Jiefang Road, Wuhan, Hubei, 430030, China.
Cell Oncol (Dordr). 2023 Aug;46(4):811-823. doi: 10.1007/s13402-023-00787-9. Epub 2023 Mar 2.
Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell death is an effective strategy to control tumor development. Pyroptosis is an inflammatory programmed cell death caused by microbial infection, accompanied by activation of inflammasomes and release of pro-inflammatory cytokines, interleukin-1β (IL-1β), and interleukin-18 (IL-18). The cleavage of gasdermins (GSDMs) promotes the occurrence of pyroptosis leading to cell swelling, lysis, and death. Accumulating evidence has indicated that pyroptosis influences the progression of HCC by regulating immune-mediated tumor cell death. Currently, some researchers hold the view that inhibition of pyroptosis-related components may prevent the incidence of HCC, but more researchers have the view that activation of pyroptosis exerts a tumor-inhibitory effect. Growing evidence indicates that pyroptosis can prevent or promote tumor development depending on the type of tumor. In this review, pyroptosis pathways and pyroptosis-related components were discussed. Next, the role of pyroptosis and its components in HCC was described. Finally, the therapeutic significance of pyroptosis in HCC was discussed.
肝细胞癌（HCC）是肝癌的主要组织学类型。它占所有肝癌诊断和死亡的大多数。诱导肿瘤细胞死亡是控制肿瘤发展的有效策略。细胞焦亡是由微生物感染引起的炎症程序性细胞死亡，伴有炎性小体的激活和促炎细胞因子白细胞介素-1β（IL-1β）和白细胞介素-18（IL-18）的释放。Gasdermins（GSDMs）的切割促进细胞肿胀、裂解和死亡的细胞焦亡的发生。越来越多的证据表明，细胞焦亡通过调节免疫介导的肿瘤细胞死亡影响 HCC 的进展。目前，一些研究人员认为抑制细胞焦亡相关成分可能预防 HCC 的发生，但更多的研究人员认为细胞焦亡的激活发挥肿瘤抑制作用。越来越多的证据表明，细胞焦亡可以根据肿瘤的类型预防或促进肿瘤的发展。在这篇综述中，讨论了细胞焦亡途径和细胞焦亡相关成分。接下来，描述了细胞焦亡及其成分在 HCC 中的作用。最后，讨论了细胞焦亡在 HCC 中的治疗意义。
